Ignite Creation Date:
2024-05-06 @ 8:21 PM
Last Modification Date:
2024-10-26 @ 3:26 PM
Study NCT ID:
NCT06359873
Status:
COMPLETED
Last Update Posted:
2024-04-11
First Post:
2024-03-26
Brief Title:
Left Atrial Enlargement A Crucial Indicator for Identifying Atrial Fibrillation in Patients With Hypertension
Sponsor:
The Second Affiliated Hospital of Chongqing Medical University
Organization:
The Second Affiliated Hospital of Chongqing Medical University
Study Overview
Official Title:
To Investigate the Early Warning Effect of CHA2DS2-VASc Score and Left Atrial Diameter on Atrial Fibrillation in Patients With Hypertension
Status:
COMPLETED
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Based on the data of inpatients with hypertension and a cross-sectional study with a large sample size this study aims to find the early warning value of the left anteroposterior atrial diameter for the possible occurrence of atrial fibrillation in patients with hypertension and compare the advantages and disadvantages of the above two methods for the early warning of the risk of atrial fibrillation in patients with hypertension so as to achieve the purpose of early identification of high-risk groups that may develop atrial fibrillation
Detailed Description:
Background Left atrial enlargement resulting from hypertension is closely linked to the development and persistence of atrial fibrillation AF The newly proposed staging recognizes AF as disease continuum which makes us aware that AF prevention should focus on the Pre-AF stage and atrial enlargement is one of the important manifestations in this stage Previous scoring systems such as CHA2DS2-VASc and C2HEST along with the recently highlighted left atrial diameter LAD have been significant tools for predicting AF occurrence However a comprehensive assessment of their utility is currently lacking
Purpose This study aims to explore the role of left atrial size in identifying atrial fibrillation AF among hospitalized hypertensives and to compare its recognition effectiveness with previous scoring systems
Methods The investigators conducted a cross-sectional analysis within hospitalized hypertensives The discovery internal and external validation datasets were established The eXtreme Gradient Boosting XGBoost was employed to identify key variables related to AF occurrence which were ranked based on their importance scores To gauge the predictive prowess of LAD regarding AF occurrence the investigators plotted the receiver operating characteristic curve ROC and calculated the area under the curve AUC This enabled us to pinpoint the LAD cutoff value corresponding to the maximum Youden index indicative of susceptibility to AF Subsequently Youden index determined the optimal cutoff value from the ROC curve Delongs test compared the identification abilities of different tools within the same dataset Logistic regression analysis assessed the correlation between clinical variables and left atrial size
Purpose This study aims to explore the role of left atrial size in identifying atrial fibrillation AF among hospitalized hypertensives and to compare its recognition effectiveness with previous scoring systems
Methods The investigators conducted a cross-sectional analysis within hospitalized hypertensives The discovery internal and external validation datasets were established The eXtreme Gradient Boosting XGBoost was employed to identify key variables related to AF occurrence which were ranked based on their importance scores To gauge the predictive prowess of LAD regarding AF occurrence the investigators plotted the receiver operating characteristic curve ROC and calculated the area under the curve AUC This enabled us to pinpoint the LAD cutoff value corresponding to the maximum Youden index indicative of susceptibility to AF Subsequently Youden index determined the optimal cutoff value from the ROC curve Delongs test compared the identification abilities of different tools within the same dataset Logistic regression analysis assessed the correlation between clinical variables and left atrial size
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None