Ignite Creation Date:
2024-05-06 @ 8:20 PM
Last Modification Date:
2024-10-26 @ 3:25 PM
Study NCT ID:
NCT06345287
Status:
RECRUITING
Last Update Posted:
2024-04-03
First Post:
2024-03-28
Brief Title:
Response Adaptive Radiotherapy Following Immunotherapy-based Induction for Non-HPV Related HNSCC
Sponsor:
Cancer Institute and Hospital Chinese Academy of Medical Sciences
Organization:
Cancer Institute and Hospital Chinese Academy of Medical Sciences
Study Overview
Official Title:
Response Adaptive Radiotherapy Following Immunotherapy-based Induction for Non-HPV Related Head and Neck Squamous Cell Carcinoma
Status:
RECRUITING
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this study is to develop an adaptive radiation therapy plan for locally advanced head and neck squamous cell carcinoma receiving induction therapy containing immunotherapy and chemotherapy The therapy plan is based on clinical remission in order to reduce treatment-related toxic side effects without sacrificing clinical efficacy and improve the quality of life of patients
Detailed Description:
Induction chemotherapy combined with immunotherapy has shown promising efficacy in locally advanced head and neck cancers However the appropriate dose and range of the following radical radiotherapy treatment remains unknown Eligibility patients were assigned to three arms depending on the degree of clinical remission clinical complete response radiotherapy 60Gy concurrent chemotherapy immunotherapy maintenance deep partial response radiotherapy 66Gy concurrent chemotherapy immunotherapy maintenance non-deep partial response radiotherapy 70Gy concurrent chemotherapy immunotherapy maintenance Progression-free survival overall survival and treatment-related toxicity would be calculated to evaluate the efficacy of treatments
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None