Ignite Creation Date:
2024-05-06 @ 8:20 PM
Last Modification Date:
2024-10-26 @ 3:25 PM
Study NCT ID:
NCT06345638
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
2024-04-03
First Post:
2024-03-12
Brief Title:
Sex Hormones and Inflammatory Biomarkers in Patients With Sickle Cell Disease
Sponsor:
University of Pennsylvania
Organization:
University of Pennsylvania
Study Overview
Official Title:
Sex Hormones and Inflammatory Biomarkers in Patients With Sickle Cell Disease
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study aims to characterize sex differences in the pathophysiology of vaso-occlusive crises VOC occurring among individuals with sickle cell disease SCD
The study will compare CRP and other biomarkers between females with SCD in the follicular phase of the menstrual cycle and males with SCD
The study will explore potential sex differences in biomarker changes between females and males with SCD during and following resolution of VOC
The study will compare neutrophil and platelet adhesion to the endothelium and real time fibrin deposition in the blood
The study will compare CRP and other biomarkers between females with SCD in the follicular phase of the menstrual cycle and males with SCD
The study will explore potential sex differences in biomarker changes between females and males with SCD during and following resolution of VOC
The study will compare neutrophil and platelet adhesion to the endothelium and real time fibrin deposition in the blood
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None