Ignite Creation Date:
2024-05-06 @ 8:20 PM
Last Modification Date:
2024-10-26 @ 3:25 PM
Study NCT ID:
NCT06344559
Status:
RECRUITING
Last Update Posted:
2024-04-03
First Post:
2024-03-27
Brief Title:
Brain Criticality Oculomotor Control and Cognitive Effort
Sponsor:
Rutgers The State University of New Jersey
Organization:
Rutgers The State University of New Jersey
Study Overview
Official Title:
Theta-burst Stimulation Modulates Criticality and Cognitive Control
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The project examines electroencephalography MRI and behavioral measures indexing flexibility critical state dynamics in the brain when healthy young adults do demanding cognitive tasks and in response to transcranial magnetic stimulation
Detailed Description:
The healthy human brain is a complex dynamical system which is hypothesized to operate at rest near a phase transition - at the boundary between order and chaos Proximity to this critical point is functionally adaptive as it affords maximal flexibility dynamic range and information transmission capacity with implications for short term memory and cognitive control Divergence from this critical point has become correlated with diverse forms of psychopathology and neuropathy suggesting that distance from a critical point is both a potential biomarker of disorder and also a target for intervention in disordered brains The Investigators have further hypothesized that task performance depends on how closely brains operate to criticality during task performance and also that subjective cognitive effort is a reflection of divergence from criticality induced by engagement with demanding tasks
A key control parameter determining distance from criticality in a resting brain is hypothesized to be the balance of cortical excitation to inhibition the EI balance Transcranial magnetic stimulation is a widely used experimental and clinical tool for neuromodulation and theta-burst stimulation TBS protocols are thought to modulate the EI balance Here the Investigators test whether cortical dynamics can be systematically modulated away from the critical point with continuous theta-burst stimulation cTBS and intermittent theta-burst stimulation iTBS which is thought to decrease and increase EI balance respectively Depending on baseline EI balance prior to stimulation this will make peoples brains either operate closer to or farther away from critiality and thereby impact on cognitive control and subjective cognitive effort during performance of control-demanding tasks
A key control parameter determining distance from criticality in a resting brain is hypothesized to be the balance of cortical excitation to inhibition the EI balance Transcranial magnetic stimulation is a widely used experimental and clinical tool for neuromodulation and theta-burst stimulation TBS protocols are thought to modulate the EI balance Here the Investigators test whether cortical dynamics can be systematically modulated away from the critical point with continuous theta-burst stimulation cTBS and intermittent theta-burst stimulation iTBS which is thought to decrease and increase EI balance respectively Depending on baseline EI balance prior to stimulation this will make peoples brains either operate closer to or farther away from critiality and thereby impact on cognitive control and subjective cognitive effort during performance of control-demanding tasks
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
True
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None