Ignite Creation Date:
2024-05-06 @ 8:20 PM
Last Modification Date:
2024-10-26 @ 3:25 PM
Study NCT ID:
NCT06343766
Status:
COMPLETED
Last Update Posted:
2024-04-03
First Post:
2024-03-19
Brief Title:
Polymorphisms in ENAM AMBN and KLK4 Contribute to DCS
Sponsor:
Amina Fouad Farag
Organization:
October 6 University
Study Overview
Official Title:
Polymorphisms in ENAM AMBN and KLK4 Predispose Egyptian Adults to Dental Caries A Cross-Sectional Study
Status:
COMPLETED
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
A Cross-Sectional Study aims to shed light on potential genetic determinants influencing dental caries susceptibility within this demographic and significantly understanding of genetic factors associated with dental caries particularly within the context of the Egyptian population providing valuable insights into the genetic aspects of oral health The research methodology involved a comprehensive examination of these polymorphic loci ENAM AMBN TUFT1 and KLK4 and their prevalence employing rigorous statistical analyses to establish potential correlations between these genetic variants and susceptibility to dental caries
Detailed Description:
The research investigates the distributional discrepancies of specific polymorphic loci ENAM rs3796703 AMBN rs4694075 TUFT1 rs13236243 and KLK4 rs2242670-within the Egyptian population as correlatives and causatives of dental caries susceptibility through the genotyping of enamelin ENAM rs3796703 ameloblastin AMBN rs4694075 tuftelin 1 TUFT1 rs78802584 and kallikrein 4 KLK4 rs2242670 in 132 adults males 74 females 58 and 72 controls males 40 females 32 referred from various Egyptian hospitals For each participant the number of decayed missing and filled teeth was charted and the presence of biofilmgingivitisfluorosis was assessed Bitewing radiographs were taken to detect interproximal caries In addition statistical analysis was conducted using Chi-square test odds ratios and corresponding P-values
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None