Ignite Creation Date:
2024-05-06 @ 8:20 PM
Last Modification Date:
2024-10-26 @ 3:25 PM
Study NCT ID:
NCT06344390
Status:
RECRUITING
Last Update Posted:
2024-04-03
First Post:
2023-12-25
Brief Title:
Effect of Pentoxifylline on Cognitive Impairment After Ischemic Stroke
Sponsor:
The First Hospital of Hebei Medical University
Organization:
The First Hospital of Hebei Medical University
Study Overview
Official Title:
Effect of Pentoxifylline on Cognitive Impairment After Ischemic Stroke and Its Mechanism of Brain Electricity and Brain Metabolism
Status:
RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Pentoxifylline can improve cognitive impairment after ischemic stroke possibly by improving the level of cerebral blood flow affecting the content of blood oxygen and metabolic substances in the brain and then playing a protective role in the transmission of nerve electrical signals and ultimately improving cognitive function The patients with cognitive impairment and non-dementia PSCIND after ischemic stroke were randomly divided into two groups In addition to the basic drugs of ischemic stroke the patients were given pentothemine sustained release tablets and blank control respectively to observe the effects of pentothemine on cognitive function and neuronal electrical signals in the patients with ischemic PSCIND It is expected to explore the possible internal biological mechanism by using transcranial Doppler oxygen-dependent functional magnetic resonance imaging and craniocerebral magnetic resonance pop analysis Finally statistical correlation analysis was used to elucidate the specific mechanism of pentoxifylline in improving cognitive function of non-dementia patients with cognitive impairment after ischemic stroke
Detailed Description:
Pentoxifylline can improve cognitive impairment after ischemic stroke possibly by improving the level of cerebral blood flow affecting the content of blood oxygen and metabolic substances in the brain and then playing a protective role in the transmission of nerve electrical signals and ultimately improving cognitive function
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None