Ignite Creation Date:
2024-05-06 @ 8:19 PM
Last Modification Date:
2024-10-26 @ 3:25 PM
Study NCT ID:
NCT06335004
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2024-03-28
First Post:
2022-05-05
Brief Title:
Evaluation of Brain Waste Clearance Pathways Using Magnetic Resonance Imaging in Pediatric Patients With White Matter Diseases
Sponsor:
IRCCS Eugenio Medea
Organization:
IRCCS Eugenio Medea
Study Overview
Official Title:
Valutazione Delle Vie Glinfatiche Utilizzando la Risonanza Magnetica Nelle Malattie Della Sostanza Bianca
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The dilation of perivascular spaces can be the result of various etiopathogenetic processes White matter atrophy can cause enlargement of these perivascular spaces PVS but also obstruction of fluid drainage systems interstitial fluid ISF and metabolites as evidenced by some recent studies Focal stagnation of liquids and deposition of toxic material induce tissue hypoxia and neuroglial dysfunction Dilation of PVS can be associated with changes in white matter and microhemorrhages We want to study these etiopathogenetic phenomena by implementing specific MRI methods
Detailed Description:
Primary objective the quantification of indirect magnetic resonance markers of altered waste drainage systems using validated scales in patients with white matter disease Secondary objective the evaluation of white matter alterations in relation to the known anatomical glymphatic pathways by analyzing both structural and diffusion data
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None