Ignite Creation Date:
2024-05-06 @ 8:19 PM
Last Modification Date:
2024-10-26 @ 3:25 PM
Study NCT ID:
NCT06337279
Status:
COMPLETED
Last Update Posted:
2024-03-29
First Post:
2024-03-22
Brief Title:
Systemic Oxidative Stress Score as a Predictor of Gastric Cancer Survival and Recurrence Risk
Sponsor:
Fujian Medical University
Organization:
Fujian Medical University
Study Overview
Official Title:
The Clinical Value of Systemic Oxidative Stress Score in Predicting Long-term Survival and Recurrence Risk in Gastric Cancer A Multicenter Real-world Cohort Study
Status:
COMPLETED
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The Systemic Oxidative Stress Score SOSS a comprehensive score reflecting the oxidative stress conditions in the microenvironment can independently and effectively predict tumor burden and long-term prognosis in GC patients Nomograms based on SOSS provide a potential and promising model for risk stratification and guiding the implementation of treatment decisions
Detailed Description:
We retrospectively analyzed the clinical data of gastric cancer patients who underwent radical gastrectomy in three hospitals from January 2009 to June 2020 The data from one hospital were randomly divided into a training cohort and an internal validation cohort in a 73 ratio while the data from the other two centers were used as an external validation cohort In the training cohort COX proportional risk models were employed to identify key indicators of SOSS and independent prognostic factors influencing patients OS and DFS Subsequently based on the results of the multifactor COX analysis two predictive models for OS and DFS were developed The predictive efficacy calibration and clinical utility of the models were evaluated using ROC curves calibration curves and decision curves in the internal and external validation cohorts respectively Both models demonstrated good discriminative ability between postoperative survival and recurrence risk outperforming TNM staging in terms of predictive accuracy
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None