Ignite Creation Date:
2024-05-06 @ 8:19 PM
Last Modification Date:
2024-10-26 @ 3:25 PM
Study NCT ID:
NCT06336382
Status:
RECRUITING
Last Update Posted:
2024-03-28
First Post:
2024-03-20
Brief Title:
Tau Biomarkers in Late-onset Psychosis LOP
Sponsor:
Jeremy Koppel
Organization:
Northwell Health
Study Overview
Official Title:
Tau Biomarkers in Late-onset Psychosis LOP
Status:
RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Hallucinations or delusions that occur for the first time in older people with no acute medical problems or mood symptoms may be related to impending dementia This study aims to confirm this hypothesis using novel blood biomarkers and Positron Emission Tomography PET imaging tracers as well as non-invasive testing
Detailed Description:
Psychotic symptoms that occur in advanced age in the absence of an acute medical condition or prominent mood symptoms can represent the late appearance of primary psychotic disorders such as very late-onset schizophrenia-like psychosis VLOSP or delusional disorder or can presage the appearance of a neurodegenerative condition such as Alzheimers disease AD An episode of non-affective psychosis late in life more than doubles the risk of subsequent neurodegenerative disease with an average time from psychosis to AD diagnosis of 18 months The biologic mechanisms responsible for the increased risk of dementia in those who experience psychosis are unclear One hypothesis is reverse causality in which inchoate neurodegeneration is responsible for psychotic symptoms that emerge in the absence of traditional cognitive hallmarks of dementia The psychosis then heralds the inception of illness that will eventuate in cognitive decline The investigators will utilize neurodegenerative biomarkers in the form of novel PET imaging tracers plasma immunoassays and non-invasive neurophysiologic measurements to test this hypothesis in a pilot cohort of elderly subjects suffering with psychosis occurring in late-life without dementia for comparison with a cohort of healthy elderly controls HECs who are participating in a study focused on those with dementia
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 1R21MH135148 | NIH | None | httpsreporternihgovquickSearch1R21MH135148 |