Ignite Creation Date:
2024-05-06 @ 8:19 PM
Last Modification Date:
2024-10-26 @ 3:25 PM
Study NCT ID:
NCT06337461
Status:
RECRUITING
Last Update Posted:
2024-03-29
First Post:
2024-03-14
Brief Title:
Computational mOdelliNg of myoCardial pERfusion to Improve ouTcome Prediction Based on cOronary Artery Stenosis and Atherosclerotic Plaque Burden Assessment by Computed Tomography
Sponsor:
Centro Cardiologico Monzino
Organization:
Centro Cardiologico Monzino
Study Overview
Official Title:
Computational mOdelliNg of myoCardial pERfusion to Improve ouTcome Prediction Based on cOronary Artery Stenosis and Atherosclerotic Plaque Burden Assessment by Computed Tomography
Status:
RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
CONCERTO
Brief Summary:
Detection of coronary stenosis is of utmost importance in identifying vulnerable patients The combined use of coronary computed tomography angiography at rest CCTA and stress myocardial computed tomography perfusion stress-CTP provides both anatomic and functional analysis of coronary artery disease CAD using a single imaging test Stress-CTP evaluates myocardial perfusion by measuring myocardial blood flow MBF under pharmacologically induced stress conditions The drawback is that stress-CTP requires additional scanning and administration of an intravenous stressor with an increase in radiation exposure and potential stressor-related side effects The investigators recently patented a computational model that can reproduce MBF under stress conditions Italian patent n 102021000031475 Metodo implementato mediante computer per la simulazione del flusso sanguigno miocardico in condizioni di stress Computational method for simulating myocardial blood flow in stress conditions half owned by Centro Cardiologico Monzino half by Politecnico di Milano
On top of this CCTA can characterize plaque type and identify adverse plaque characteristics Moreover biomechanics analysis allows the study of luminal stenosis and stress within the plaque Finally radiomics extracting quantitative features from medical images to create big data and identify novel imaging biomarkers can be applied to improve the diagnostic accuracy of coronary plaques
On top of this CCTA can characterize plaque type and identify adverse plaque characteristics Moreover biomechanics analysis allows the study of luminal stenosis and stress within the plaque Finally radiomics extracting quantitative features from medical images to create big data and identify novel imaging biomarkers can be applied to improve the diagnostic accuracy of coronary plaques
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None