Ignite Creation Date:
2024-05-06 @ 8:19 PM
Last Modification Date:
2024-10-26 @ 3:25 PM
Study NCT ID:
NCT06336694
Status:
COMPLETED
Last Update Posted:
2024-03-29
First Post:
2023-11-26
Brief Title:
A Deep Learning Radiomics Model for Predicting Occult Peritoneal Metastases of Pancreatic Adenocarcinoma
Sponsor:
First Affiliated Hospital Sun Yat-Sen University
Organization:
First Affiliated Hospital Sun Yat-Sen University
Study Overview
Official Title:
Development and Validation of a Deep Learning Radiomics Model With Clinical-radiological Characteristics for the Identification of Occult Peritoneal Metastases in Patients With Pancreatic Ductal Adenocarcinoma
Status:
COMPLETED
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Occult peritoneal metastases OPM in patients with pancreatic ductal adenocarcinoma PDAC are frequently overlooked during imaging We aimed to develop and validate a CT-based deep learning-based radiomics DLR model with clinical-radiological characteristics to identify OPM in patients with PDAC before treatment
Detailed Description:
This retrospective bicentric study included 302 patients with PDAC training n 167 OPM-positive n22 internal test n 72 OPM-positive n9 external test n63 OPM-positive n9 who had undergone baseline CT examinations between January 2012 and October 2022 Handcrafted radiomics HCR and DLR features of the tumor and HCR features of peritoneum were extracted from CT images Mutual information and least absolute shrinkage and selection operator algorithms were used for feature selection A combined model which incorporated the selected clinical-radiological HCR and DLR features was developed using a logistic regression classifier using data from the training cohort and validated in the test cohorts
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None