Ignite Creation Date:
2024-05-06 @ 8:18 PM
Last Modification Date:
2024-10-26 @ 3:25 PM
Study NCT ID:
NCT06334562
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-03-28
First Post:
2024-03-14
Brief Title:
The Clinical Effect of Sugammadex Sodium Domestic for Antagonizing Neuromuscular Blockade After Thoracic Surgery
Sponsor:
The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Organization:
The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Study Overview
Official Title:
An Observational Study on the Clinical Effect of Sugammadex Sodium Domestic for Antagonizing Neuromuscular Blockade After Thoracic Surgery
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study aims to compare the use of sugammadex domestic and neostigmine for antagonism after thoracic surgery and observe the effect of sugammadex domestic on neuromuscular blockade antagonism after thoracic surgery in order to provide a basis for optimizing the use of muscle relaxants and their antagonists during anesthesia
Detailed Description:
All patients were well prepared preoperatively and vital signs monitoring and accelerated muscle relaxation monitor and TOF monitoring of muscle relaxation were improved after admission General anaesthesia was induced and maintained by an experienced anaesthesiologist according to the routine drug administration protocol The neuromuscular blocking drug was limited to rocuronium bromide at an induction dose of 06 mgkg Anaesthesia was induced with intravenous propofol and maintained with sevoflurane and rocuronium bromide 015 mgkg At the end of surgery when the patients degree of neuromuscular blockade spontaneously recovered to T2 reappearance the neuromuscular blocking effect of rocuronium bromide was reversed by intravenous rapid injection of sugammadex domestic injection or neostigmine within 10 s The dose of sugammadex domestic was 2 mgkg and neostigmine 50 μgkg Information on dosage and time of neuromuscular blocking medication was recorded and the patients were recorded at the end of the surgery Neuromuscular function and clinical performance after reversal with sugammadex domestic at the end of the procedure recording the recovery time of neuromuscular function extubation time and time of leaving the room
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None