Ignite Creation Date:
2024-05-06 @ 8:18 PM
Last Modification Date:
2024-10-26 @ 3:25 PM
Study NCT ID:
NCT06336174
Status:
RECRUITING
Last Update Posted:
2024-04-02
First Post:
2024-03-22
Brief Title:
Cognitive Decline and Underlying Mechanisms in Symptomatic Intracranial Artery Stenosis Patients A Cohort Study
Sponsor:
Anhui Medical University
Organization:
Anhui Medical University
Study Overview
Official Title:
Cognitive Decline and Underlying Mechanisms in Symptomatic Intracranial Atherosclerotic Stenosis Patients A Multicenter Cohort Study
Status:
RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to explore the mechanism of cognitive impairment in patients with symptomatic intracranial atherosclerotic stenosis ICAS and further plans to explore the impact of different treatment options on cognitive function in symptomatic ICAS patients
Detailed Description:
All participants underwent a medical evaluation that included routine laboratory studies before and after 3-month and 1-year follow-up Upon meeting the inclusion criteria and providing informed consent each participant will complete a battery measure of neuropsychological tests blood sample collection and magnetic resonance imaging scan after enrollment and after 3-month and 1-year follow-up
About 100 participants were included in this study A series of neuropsychological tests were obtained by a trained investigator to assess The tests include the evaluation of global cognitive function and multiple individual cognitive domains The various tasks and questionnaires to measure cognition function including Montreal Cognitive Assessment MoCA Mini Mental State Examination MMSE Chinese Auditory Verbal Learning Test CAVLT Digital Span Test DST Stroop color test Stroop test Color trail test CTT Clock Drawing Test CDT Verbal Fluency Test VFT etc at the same time the investigators also pay attention to the evaluation of participants emotions by Hamilton Anxiety Scale HAMA Hamilton Depression Scale HAMD Furthermore the memory and the occurrence of cerebrovascular events as the primary outcome measure this study focused on the multidimensional cognitive function and cerebrovascular events of patients with symptomatic ICAS Blood sample will be collected for biological multiomics research The patients will receive a magnetic resonance imaging scan in multi-modalities
After 3-month and 1-year follow-up the participants will be interviewed to obtain the same assessments blood sample and magnetic resonance imaging scan in multi-modalities as before
About 100 participants were included in this study A series of neuropsychological tests were obtained by a trained investigator to assess The tests include the evaluation of global cognitive function and multiple individual cognitive domains The various tasks and questionnaires to measure cognition function including Montreal Cognitive Assessment MoCA Mini Mental State Examination MMSE Chinese Auditory Verbal Learning Test CAVLT Digital Span Test DST Stroop color test Stroop test Color trail test CTT Clock Drawing Test CDT Verbal Fluency Test VFT etc at the same time the investigators also pay attention to the evaluation of participants emotions by Hamilton Anxiety Scale HAMA Hamilton Depression Scale HAMD Furthermore the memory and the occurrence of cerebrovascular events as the primary outcome measure this study focused on the multidimensional cognitive function and cerebrovascular events of patients with symptomatic ICAS Blood sample will be collected for biological multiomics research The patients will receive a magnetic resonance imaging scan in multi-modalities
After 3-month and 1-year follow-up the participants will be interviewed to obtain the same assessments blood sample and magnetic resonance imaging scan in multi-modalities as before
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None