Ignite Creation Date:
2024-05-06 @ 8:18 PM
Last Modification Date:
2024-10-26 @ 3:25 PM
Study NCT ID:
NCT06331897
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-03-26
First Post:
2024-03-16
Brief Title:
Bronchial Asthma Its Exacerbation
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Assessment of Bronchial Asthma Its Exacerbation the Utility of Laboratory Investigation Chest Imaging Pulmonary Function Tests
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Our goals is to assess
1_ the role of spirometer in case of asthma exacerbation 2_hematological parameters NL ratio amp platelet indices ampCRP in asthma exacerbation for diagnosing and classifying asthma severity and its exacerbation
1_ the role of spirometer in case of asthma exacerbation 2_hematological parameters NL ratio amp platelet indices ampCRP in asthma exacerbation for diagnosing and classifying asthma severity and its exacerbation
Detailed Description:
Bronchial asthma is a chronic inflammatory disease characterized by bronchial hyper-reactivity reversible airway obstruction and excessive mucus production that arises from an inappropriate stimulation of the immune system especially by environmental aeroallergens Bronchial asthma exacerbations are episodes described by progressive increase in symptoms of cough wheezing shortness of breath andor chest tightness with a progressive decrease in lung function Few tests are being used for diagnosis of asthma but at present no established biomarker is available that may be used for diagnosis and prognosis of asthma Platelet indices and C-reactive protein CRP are markers that reflect a systemic inflammatory response Bronchial obstruction variable over time and reversible after using bronchodilator is the hallmark of the respiratory function in bronchial asthma There are patients with 34atypical34 functional tests or in whom routine tests spirometry peak-flowmetry are not sufficient for asthma diagnosis thus necessitating more complex functional tests Pulmonary function evaluation confirms the diagnostic establishes disease severity and contributes to disease monitoring Quality criteria verification eg acceptability of the measurements and reproducibility of the parameters should precede any interpretation Neutrophilic eosinophilic paucigranulocytic or mixed granulocytic types are four various endotypes of asthma 6 depending on cell counts of peripheral blood
Neutrophilic inflammations have been studied to be associated with a poor asthma control In addition to persistent asthma symptoms and atopy they have been reported to be associated with the presence of eosinophilic inflammation in asthmatic patients Accordingly NLR increase in asthmatics was considered However data related to NLR in Asthmatic patients is inadequate Though association between asthma and NLR was discovered by earlier researches in adults recent researches did not study NLR relation to neutrophilic asthma So we aimed to assess the relation of NLR and bronchial asthma severity and to determine NLR discriminative performance between controlled and uncontrolled asthma Platelet indices which include the mean platelet volume MPV platelet distribution width PDW plateletcrit PCT and platelet large cell correlated with white blood cells PaO2 and symptoms duration and negatively correlated with forced expiratory volume in the first second symptoms duration and hs-CRP Plt0001
Higher autophagy of neutrophils has been described in many pulmonary disorders as well as neutrophil extracellular traps and exosomes that has been newly studied as deriving from neutrophil So neutrophils role in pulmonary diseases have been established Despite pulmonary diseases pathogeneses are being studied widely there is still more and more to get clarification of the discrepancy and complexity particularly the contribution of different immune mechanisms in the progress of pulmonary disorders
Neutrophilic inflammations have been studied to be associated with a poor asthma control In addition to persistent asthma symptoms and atopy they have been reported to be associated with the presence of eosinophilic inflammation in asthmatic patients Accordingly NLR increase in asthmatics was considered However data related to NLR in Asthmatic patients is inadequate Though association between asthma and NLR was discovered by earlier researches in adults recent researches did not study NLR relation to neutrophilic asthma So we aimed to assess the relation of NLR and bronchial asthma severity and to determine NLR discriminative performance between controlled and uncontrolled asthma Platelet indices which include the mean platelet volume MPV platelet distribution width PDW plateletcrit PCT and platelet large cell correlated with white blood cells PaO2 and symptoms duration and negatively correlated with forced expiratory volume in the first second symptoms duration and hs-CRP Plt0001
Higher autophagy of neutrophils has been described in many pulmonary disorders as well as neutrophil extracellular traps and exosomes that has been newly studied as deriving from neutrophil So neutrophils role in pulmonary diseases have been established Despite pulmonary diseases pathogeneses are being studied widely there is still more and more to get clarification of the discrepancy and complexity particularly the contribution of different immune mechanisms in the progress of pulmonary disorders
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None