Ignite Creation Date:
2024-05-06 @ 8:18 PM
Last Modification Date:
2024-10-26 @ 3:25 PM
Study NCT ID:
NCT06339697
Status:
COMPLETED
Last Update Posted:
2024-04-01
First Post:
2024-02-28
Brief Title:
Short-term Effects of Bowel Preparation on Gut Microbiome in Patients Undergoing Endoscopic Colon Polypectomy
Sponsor:
Zhang Yanli
Organization:
China-Japan Friendship Hospital
Study Overview
Official Title:
Short-term Effects of Bowel Preparation on Gut Microbiome in Patients Undergoing Endoscopic Colon Polypectomy
Status:
COMPLETED
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To investigate the role of different types of laxatives compounded polyethylene glycol electrolyte dispersions and compounded sodium pico-sulfate on the composition evolution and recovery of the gut microbiome of patients with colonic polyps undergoing bowel preparation
Detailed Description:
Good and adequate bowel preparation is essential for colonoscopy especially in patients requiring endoscopic treatment and the role of bowel purgatives and their safety for patients has been extensively studied There are several laxatives available in clinical practice the most widely used being electrolyte-supplemented polyethylene glycol PEG solutions and other types of laxatives such as compound sodium picosulfate SP have been developed subsequently
When a large amount of laxative passes through the intestine many microorganisms are removed from the intestine Thus leading to significant changes in the composition of the intestinal microbiota during intestinal cleansing There is no consensus on how gut cleansing affects the gut microbiome
There are no studies exploring whether there are differences in the effects of different types of laxatives on the human gut microbiome In this study focusing on patients diagnosed with colon polyps the investigators explored the effects on the composition evolution recovery and functional pathways of the patients gut microbiome after the use of different types of laxatives and endoscopic treatment
When a large amount of laxative passes through the intestine many microorganisms are removed from the intestine Thus leading to significant changes in the composition of the intestinal microbiota during intestinal cleansing There is no consensus on how gut cleansing affects the gut microbiome
There are no studies exploring whether there are differences in the effects of different types of laxatives on the human gut microbiome In this study focusing on patients diagnosed with colon polyps the investigators explored the effects on the composition evolution recovery and functional pathways of the patients gut microbiome after the use of different types of laxatives and endoscopic treatment
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None