Ignite Creation Date:
2024-05-06 @ 8:18 PM
Last Modification Date:
2024-10-26 @ 3:24 PM
Study NCT ID:
NCT06321861
Status:
RECRUITING
Last Update Posted:
2024-03-20
First Post:
2024-01-17
Brief Title:
Motivational Affective and Performance Effects of Caffeine Supplementation
Sponsor:
Jagiellonian University
Organization:
Jagiellonian University
Study Overview
Official Title:
The Effects of Caffeine Supplementation on Motivation Affect and Performance in Physical Exercise Tests An Intervention Study
Status:
RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The main objective of the study is to evaluate the influence of caffeine intake on participants energetic arousal affect motivation to achieve a training goal satisfaction with training and the sense of agency during training Consequently participants will engage in three sessions caffeine placebo and no substance in counterbalanced order During each session their affective and motivational states will be assessed along with the performance of a standardized physical exercise test The investigators hypothesize that participants who consume caffeine caffeine condition will exhibit higher levels of energy and motivation compared to the other two groups Additionally they are expected to experience greater optimism and expectancy regarding their training goals and achieve better results in the physical exercise test
A secondary aim of the study is to examine the impact of genetic variability on motivational and affective states of participants as well as their performance in the physical exercise test after caffeine The investigators will assess the CYP1A2 -163C A rs762551 characterized such as fast AA genotype and slow caffeine metabolizers C-carriers and ADORA2A 1976T C rs5751876 characterized by high TT genotype or low sensitivity to caffeine C-carriers
A secondary aim of the study is to examine the impact of genetic variability on motivational and affective states of participants as well as their performance in the physical exercise test after caffeine The investigators will assess the CYP1A2 -163C A rs762551 characterized such as fast AA genotype and slow caffeine metabolizers C-carriers and ADORA2A 1976T C rs5751876 characterized by high TT genotype or low sensitivity to caffeine C-carriers
Detailed Description:
Before participating in the study participants will answer questions regarding their consumption of caffeinated beverages and the frequency of their workouts They will also complete the Extreme Personality Scale measuring the tendency to pursue goals single-mindedly Subsequently they will be qualified for the study based on the questionnaire results and a brief interview
The study will involve the manipulation of energization through the administration of caffeine Participants will take part in a randomized crossover double-blind study where they will perform three identical training sessions after consuming a caffeine at a dose of 3 mgkg of body weight b a placebo and c under control conditions ie without substance administration Capsule consumption will occur 60 minutes before the start of the training Caffeine and placebo capsules will not differ in size shape color and taste
As the effectiveness of caffeine use depends on the CYP1A2 rs762551 and ADORA2 rs5751876 gene polymorphisms the study will also genotype these genes The first gene is responsible for the rate of caffeine metabolism determining whether people metabolize caffeine fast or slow The ADORA2A gene encoding the adenosine A2A receptor influences how sensitive people are to caffeine DNA isolates obtained from oral epithelial cells collected from participants by qualified medical personnel will constitute the research material Oral epithelial swabs will be collected directly from the participants into sterile tubes
Before and after substance intake and additionally after the exercise test participants will assess their arousal using the University of Wales Institute of Science and Technology Mood Adjective Checklist Additionally after substance intake and before exercise participants will answer questions about motivation affect and expectancy regarding training Subsequently participants will undergo training taking the form of a supervised standardized exercise test After exercise participants will assess their satisfaction and feelings after completing the training
The study will involve the manipulation of energization through the administration of caffeine Participants will take part in a randomized crossover double-blind study where they will perform three identical training sessions after consuming a caffeine at a dose of 3 mgkg of body weight b a placebo and c under control conditions ie without substance administration Capsule consumption will occur 60 minutes before the start of the training Caffeine and placebo capsules will not differ in size shape color and taste
As the effectiveness of caffeine use depends on the CYP1A2 rs762551 and ADORA2 rs5751876 gene polymorphisms the study will also genotype these genes The first gene is responsible for the rate of caffeine metabolism determining whether people metabolize caffeine fast or slow The ADORA2A gene encoding the adenosine A2A receptor influences how sensitive people are to caffeine DNA isolates obtained from oral epithelial cells collected from participants by qualified medical personnel will constitute the research material Oral epithelial swabs will be collected directly from the participants into sterile tubes
Before and after substance intake and additionally after the exercise test participants will assess their arousal using the University of Wales Institute of Science and Technology Mood Adjective Checklist Additionally after substance intake and before exercise participants will answer questions about motivation affect and expectancy regarding training Subsequently participants will undergo training taking the form of a supervised standardized exercise test After exercise participants will assess their satisfaction and feelings after completing the training
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None