Ignite Creation Date:
2024-05-06 @ 8:18 PM
Last Modification Date:
2024-10-26 @ 3:24 PM
Study NCT ID:
NCT06325072
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2024-03-22
First Post:
2024-02-29
Brief Title:
Set-up of a Platform for Personalized Diagnosis of Rare Kidney Diseases NIKE
Sponsor:
Meyer Childrens Hospital IRCCS
Organization:
Meyer Childrens Hospital IRCCS
Study Overview
Official Title:
Set-up of a Platform for Personalized Diagnosis of Rare Kidney Diseases NIKE
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Chronic kidney disease CKD is a major health problem with steadily increasing incidence and prevalence and the threat of a true epidemic Converging evidence suggests a high prevalence of genetic etiology in rare kidney diseases and the list of new disease-causing genes is constantly updated Recent advances in next-generation sequencing NGS technologies have prompted a significant improvement in the diagnosis of rare kidney diseases Notwithstanding this NGS generates high numbers of information that need to be properly analysed by the joint efforts of geneticists nephrologists and bioinformatics in order to integrate clinical and genetic information in a personalized manner In addition in selected cases the contribution of researchers proves essential for the development of experimental models of the disease to study and understand the pathogenic features and propose a personalized therapeutic approach Such an innovative integrated diagnostic paradigm is currently available in few centers all over the world and cannot be easily translated in daily clinical practice
The aim of the study is to set-up an integrated diagnostic algorithm to extend the newest personalized diagnostic and treatment strategies for rare kidney diseases to all patients in the Tuscany region under 40 years of age with kidney disease This algorithm will be based on a constant cross-talk between participating centers and a dedicated multidisciplinary team Diagnostic and therapeutic performances will be validated at European level
The aim of the study is to set-up an integrated diagnostic algorithm to extend the newest personalized diagnostic and treatment strategies for rare kidney diseases to all patients in the Tuscany region under 40 years of age with kidney disease This algorithm will be based on a constant cross-talk between participating centers and a dedicated multidisciplinary team Diagnostic and therapeutic performances will be validated at European level
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None