Ignite Creation Date:
2024-05-06 @ 8:17 PM
Last Modification Date:
2024-10-26 @ 3:24 PM
Study NCT ID:
NCT06325501
Status:
RECRUITING
Last Update Posted:
2024-03-22
First Post:
2024-03-16
Brief Title:
Misoprostol Versus Oxytocin Infusion On Reducing Blood Loss During Abdominal Myomectomy
Sponsor:
Cairo University
Organization:
Cairo University
Study Overview
Official Title:
The Efficacy Of Misoprostol Versus Oxytocin Infusion On Reducing Blood Loss During Abdominal Myomectomy
Status:
RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Uterine leiomyomas or fibroids are common benign tumors among women especially those over 35 years old They can cause various issues including heavy menstrual bleeding anemia pelvic pain and pressure symptoms Surgery is often necessary for symptomatic fibroids with hysterectomy recommended for women over 40 and myomectomy for those wishing to preserve their uterus Myomectomy can be performed using different surgical approaches but can be associated with significant morbidity particularly major blood loss especially in abdominal myomectomy where up to 20 of women may require blood transfusion
Various interventions have been introduced to reduce bleeding during myomectomy such as tourniquets bupivacaine plus epinephrine infiltration vasopressin injection preoperative GnRH agonist administration and preoperative ascorbic acid injection However these strategies may have complications be ineffective expensive or require extra steps
Oxytocin primarily secreted from the pituitary gland is crucial for uterine contraction during labor and delivery and is used to prevent postpartum uterine atony and bleeding However caution is needed in its use especially in women with heart disease or hypovolemia
Misoprostol a prostaglandin E1 analogue can reduce bleeding during myomectomy by promoting myometrial contractions and reducing uterine artery blood flow It can be administered via multiple routes with rectal administration showing advantages in maintaining high plasma concentrations during surgery Studies have investigated the effectiveness of single preoperative rectal doses of misoprostol versus preoperative oxytocin in reducing bleeding during abdominal myomectomy
Various interventions have been introduced to reduce bleeding during myomectomy such as tourniquets bupivacaine plus epinephrine infiltration vasopressin injection preoperative GnRH agonist administration and preoperative ascorbic acid injection However these strategies may have complications be ineffective expensive or require extra steps
Oxytocin primarily secreted from the pituitary gland is crucial for uterine contraction during labor and delivery and is used to prevent postpartum uterine atony and bleeding However caution is needed in its use especially in women with heart disease or hypovolemia
Misoprostol a prostaglandin E1 analogue can reduce bleeding during myomectomy by promoting myometrial contractions and reducing uterine artery blood flow It can be administered via multiple routes with rectal administration showing advantages in maintaining high plasma concentrations during surgery Studies have investigated the effectiveness of single preoperative rectal doses of misoprostol versus preoperative oxytocin in reducing bleeding during abdominal myomectomy
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None