Ignite Creation Date:
2024-05-06 @ 8:17 PM
Last Modification Date:
2024-10-26 @ 3:24 PM
Study NCT ID:
NCT06325098
Status:
RECRUITING
Last Update Posted:
2024-03-22
First Post:
2024-03-01
Brief Title:
Implementation of a Diagnostic Workflow for Personalized Diagnosis of Nephrotic Syndrome
Sponsor:
Meyer Childrens Hospital IRCCS
Organization:
Meyer Childrens Hospital IRCCS
Study Overview
Official Title:
Implementation of a Diagnostic Workflow for Personalized Diagnosis of Nephrotic Syndrome
Status:
RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Nephrotic syndrome NS is a clinical picture common to several diseases resulting from damage to podocytes and glomerular filtration barrier Currently there is limited consensus regarding the diagnostic pathway and management of the specific etiology Some patients show complete response to first-line steroid therapy steroid-sensitive nephrotic syndrome SSNS especially in children and young adults The prognosis of this group is generally favorable In contrast patients unresponsive to steroids steroid-resistant NS SRNS frequently undergo immunosuppressive therapies which are burdened with numerous side effects Resistance to treatment is associated with a high likelihood of progression to chronic renal disease CKD and kidney failure ESKD Recent evidence suggests that immunological mechanisms including permeabilizing factors are involved in the pathogenesis of post-transplant NS recurrence and SSNS
Providing patients with NS with a correct diagnosis is the cornerstone of personalized medicine reducing morbidity and side effects of therapies ensuring their appropriate prescription and slowing or preventing progression to ESKD
Providing patients with NS with a correct diagnosis is the cornerstone of personalized medicine reducing morbidity and side effects of therapies ensuring their appropriate prescription and slowing or preventing progression to ESKD
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None