Ignite Creation Date:
2024-05-06 @ 8:16 PM
Last Modification Date:
2024-10-26 @ 3:24 PM
Study NCT ID:
NCT06327503
Status:
COMPLETED
Last Update Posted:
2024-05-07
First Post:
2024-03-18
Brief Title:
Salivary Signal Molecules for Neural and Vascular Homeostasis in T2DM
Sponsor:
University of Belgrade
Organization:
University of Belgrade
Study Overview
Official Title:
Salivary Signal Molecules Relevant for Neural and Vascular Homeostasis in Patients With Type 2 Diabetes Mellitus
Status:
COMPLETED
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Various signal molecules are detected in blood and tissues of patients with T2DM that are important for the function of neural tissue in diabetic setting Among them specifically important are neuroprotective and neurotrophic growth factors such as nerve growth factor NGF glial cells - derived neurotrophic factor GDNF and brain-derived neurotrophic factor BDNF Furthermore several other signal molecules are discovered to affect vascular tissues homeostasis in T2DM including soluble alpha-klotho s-Klotho vascular endothelial growth factor VEGF and interleukin-6 IL-6 Most of these molecules are also detected in saliva in various states and diseases of orofacial system but data about their levels in saliva of T2DM patients are lacking although neural and vascular diabetic complications are present in orofacial tissues and organs Also there is no data about presence and levels of s-Klotho in saliva of healthy or T2DM patients although it was reported that this molecule exerts protective effect on the salivary glands tissue Salivary opiorphin is recently discovered pentapeptide primarily isolated from saliva It acts as an inhibitor of the enzymes that perform degradation of endogenous antinociceptive molecules enkephalins affecting nociceptive signal transduction This may be of special importance since some intraoral complications of T2DM eg burning mouth may have underlying peripheral neural changes as a pathophysiological mechanism Against this background the aim of the study is to detect the presence and levels of mentioned signal molecules in saliva of patients with and without T2DM
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None