Ignite Creation Date:
2024-05-06 @ 8:16 PM
Last Modification Date:
2024-10-26 @ 3:24 PM
Study NCT ID:
NCT06324552
Status:
RECRUITING
Last Update Posted:
2024-06-14
First Post:
2024-03-15
Brief Title:
Defects of Keratinocytes Function in Dermatologic Patients
Sponsor:
IRCCS Burlo Garofolo
Organization:
IRCCS Burlo Garofolo
Study Overview
Official Title:
Defects of Keratinocytes Function in Dermatologic Patients Carrying Genetic Variants Involved in NOTCH Signaling
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
NOTCH signaling in the skin exerts a pivotal role in the regulation of normal keratinocytes turnover by mediating the balance between proliferation differentiation apoptosis and autophagic flux progression Two skin diseases are characterized by the presence of gene variants that cause an impairment in NOTCH signaling hidradenitis suppurativaHS and Dowling-Degos diseaseDDD To date both HS and DDD are orphan diseases still lacking of specific treatments This project aims at improving the current knowledge on the pathogenesis of HS and DDD by deepening the understandings on the role played by keratinocytes in these pathologies and also by determining why mutations found in the same pathway cause different diseases This study aimed to obtain in vitro models derived directly from patients from hair follicles and from keratinocytes HaCaT cell cultures for the study of these skin pathologies and also for the testing of novel innovative therapies such as photobiomodulation therapy
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None