Ignite Creation Date:
2024-05-06 @ 8:16 PM
Last Modification Date:
2024-10-26 @ 3:23 PM
Study NCT ID:
NCT06311890
Status:
RECRUITING
Last Update Posted:
2024-03-15
First Post:
2024-01-14
Brief Title:
Study to Evaluate the Efficacy Safety and Tolerability of Photodynamic TherapyPDT With Chlorin-e6 in Treating Moderate to Severe Acne
Sponsor:
Xiyuan Hospital of China Academy of Chinese Medical Sciences
Organization:
Xiyuan Hospital of China Academy of Chinese Medical Sciences
Study Overview
Official Title:
Study to Evaluate the Efficacy Safety and Tolerability of Photodynamic TherapyPDT With Chlorin-e6 in Treating Moderate to Severe Acne
Status:
RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study aims to evaluate the clinical efficacy safety and tolerability of a photodynamic therapyPDT based on a new photosensitizer Chlorin-e6 in the treatment of moderate to severe acne The hypothesis is that the therapy has good efficacy safety and tolerability
Detailed Description:
The acne clinical guidelines all recommend PDT as an alternative therapy for moderate to severe acne based on the excellent performance of ALA-PDT in the treatment of acne vulgaris Photosensitizers including Porphyrin and Chlorin have also proved to play a positive role in reducing the number of skin lesions and microbial load Researchers have successfully provided basic evidence that Chlorin-e6 induces inflammation inhibition through AP-1 NF-κB MAPKs and other pathways of propionibacterium acnes and increases collagen expression in HaCaT cells which undoubtedly further indicates As a new type of photosensitive material Chlorin-e6 derivatives have excellent performance in the face of moderate and severe acne with high levels of inflammation and high risk of scar
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None