Ignite Creation Date:
2024-05-06 @ 8:16 PM
Last Modification Date:
2024-10-26 @ 3:24 PM
Study NCT ID:
NCT06317142
Status:
RECRUITING
Last Update Posted:
2024-04-09
First Post:
2023-08-07
Brief Title:
Glucose and Glycogen Dynamics in Prediabetes
Sponsor:
Maastricht University Medical Center
Organization:
Maastricht University Medical Center
Study Overview
Official Title:
Investigating Disturbances in Glucose and Glycogen Dynamics in Prediabetes
Status:
RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
GGD
Brief Summary:
The goal of this observational study is to investigate changes in nocturnal and postprandial glucose and glycogen metabolism in individuals with impaired fasting glucose and impaired glucose tolerance compared to healthy non-diabetic overweight participants 15 per group In addition it will be investigated if reducing gluconeogenesis by using the challenge agent Acipimox in people with prediabetes can increase glucose tolerance and fat oxidation by increased reliance on hepatic glycogen The main questions this project aims to answer are
whether there are differences in nocturnal glucoseglycogen metabolism in individuals with impaired fasting glucose impaired glucose tolerance and healthy overweight controls
whether there are differences in postprandial glucoseglycogen metabolism in individuals with impaired fasting glucose impaired glucose tolerance and healthy overweight controls
Participants will visit the university for a screening visit and a visit with overnight stay for measurements of gluconeogenesis glycogen and substrate oxidation A subgroup will receive 18F-FDG to assess tissue-specific postprandial glucose uptake Thereafter 20 prediabetic individuals will follow a 4-day treatment with acipimox to decrease gluconeogenesis followed by a second overnight visit with similar measurements as mentioned for the first visit
whether there are differences in nocturnal glucoseglycogen metabolism in individuals with impaired fasting glucose impaired glucose tolerance and healthy overweight controls
whether there are differences in postprandial glucoseglycogen metabolism in individuals with impaired fasting glucose impaired glucose tolerance and healthy overweight controls
Participants will visit the university for a screening visit and a visit with overnight stay for measurements of gluconeogenesis glycogen and substrate oxidation A subgroup will receive 18F-FDG to assess tissue-specific postprandial glucose uptake Thereafter 20 prediabetic individuals will follow a 4-day treatment with acipimox to decrease gluconeogenesis followed by a second overnight visit with similar measurements as mentioned for the first visit
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None