Ignite Creation Date:
2024-05-06 @ 8:16 PM
Last Modification Date:
2024-10-26 @ 3:24 PM
Study NCT ID:
NCT06314191
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-05-17
First Post:
2024-03-01
Brief Title:
Adipose Tissue and Symptomatic Gonarthrosis
Sponsor:
Centre Hospitalier Universitaire de Nice
Organization:
Centre Hospitalier Universitaire de Nice
Study Overview
Official Title:
Comparative Study to Identify Biomarkers of Visceral Adipose Tissue Responsible for Symptomatic Gonarthrosis in Obese Patients
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
TAGS
Brief Summary:
1 Prevalence of osteoarthritis in France Osteoarthritis OA is a very common disease affecting almost 15 of the population It is responsible for a significant socio-economic cost in connection with the chronic and disabling pain it causes Gonarthrosis is the most frequently encountered arthritic localization In a large 2010 meta-analysis the main risk factors for developing knee OA were shown to be obesity previous knee trauma hand OA female gender and advanced age Smoking appeared to have a moderate protective effect The risk of developing gonarthrosis in obese patients is 26 times higher than in the general population Hypercholesterolemia itself is a risk factor for osteoarthritis as are increased plasma levels of specific fatty acids and lipoproteins Inflammatory mechanism in osteoarthritis Studies have shown that plasma levels of C-reactive protein can be used to estimate individual susceptibility to developing osteoarthritis over a lifetime In osteoarthritis patients plasma concentrations of TNF-α IL-6 and IL-1 are abnormally high which appears to contribute to cartilage loss in these subjects
3 Inflammatory mechanism in obesity Obesity induces systemic and local joint mechanical stresses that increase the risk of developing gonarthrosis in obese or overweight individuals Beyond the simple mechanical aspect a body of evidence supports the assertion that obesity is responsible for a systemic inflammatory state deleterious to joints 1 Obesity is associated with radiographic and symptomatic osteoarthritis in non-weight-bearing joints such as the hand In overweight and obese adults plasma levels of tumor necrosis factor alpha TNF-α and interleukin-6 IL-6 are significantly increased
3Weight loss in obese subjects with osteoarthritis alleviates joint symptoms through reduced mechanical stress but also through reduced production and response of inflammatory products
4 Common inflammatory mechanisms between adipose tissue and obesity The relationship between adipose tissue and inflammation is complex given the different types of adipose tissue and the action of cells derived from it Adipose tissue is an active endocrine organ composed of mature and developing adipocytes as well as fibroblasts endothelial cells and a wide range of immune cells namely adipose tissue macrophages neutrophils eosinophils mast cells T cells and B cells Adipose tissue is recognized as an endocrine organ that secretes a large number of inflammatory mediators including cytokines IL-1 IL-6 IL-8 TNF-α and adipokines leptin adiponectin resistin visfatin Communication between adipocytes and immune cells maintains tissue homeostasis Obesity however can upset this balance
Lipid metabolism and joint disorders have been shown to be linked A high-fat diet may contribute to the development of osteoarthritis
White and brown adipose tissue appear to play a complementary role in the development of osteoarthritis Increased white adipose tissue in obesity is thought to create a systemic environment of increased inflammation through the release of pro-inflammatory cytokines and adipokines such as leptin and visfatin all of which have been associated with osteoarthritis Locally white adipocytes in infra patellar adipose tissue are architecturally different in patients without gonarthrosis compared with those with knee osteoarthritis This difference suggests that adipocyte gene expression is directly influenced by inflammation In obese individuals there is elevated IL-6 production in brown adipose tissue Furthermore it would appear that brown adipose tissue unlike white down-regulates the inflammatory profile of macrophages
3 Inflammatory mechanism in obesity Obesity induces systemic and local joint mechanical stresses that increase the risk of developing gonarthrosis in obese or overweight individuals Beyond the simple mechanical aspect a body of evidence supports the assertion that obesity is responsible for a systemic inflammatory state deleterious to joints 1 Obesity is associated with radiographic and symptomatic osteoarthritis in non-weight-bearing joints such as the hand In overweight and obese adults plasma levels of tumor necrosis factor alpha TNF-α and interleukin-6 IL-6 are significantly increased
3Weight loss in obese subjects with osteoarthritis alleviates joint symptoms through reduced mechanical stress but also through reduced production and response of inflammatory products
4 Common inflammatory mechanisms between adipose tissue and obesity The relationship between adipose tissue and inflammation is complex given the different types of adipose tissue and the action of cells derived from it Adipose tissue is an active endocrine organ composed of mature and developing adipocytes as well as fibroblasts endothelial cells and a wide range of immune cells namely adipose tissue macrophages neutrophils eosinophils mast cells T cells and B cells Adipose tissue is recognized as an endocrine organ that secretes a large number of inflammatory mediators including cytokines IL-1 IL-6 IL-8 TNF-α and adipokines leptin adiponectin resistin visfatin Communication between adipocytes and immune cells maintains tissue homeostasis Obesity however can upset this balance
Lipid metabolism and joint disorders have been shown to be linked A high-fat diet may contribute to the development of osteoarthritis
White and brown adipose tissue appear to play a complementary role in the development of osteoarthritis Increased white adipose tissue in obesity is thought to create a systemic environment of increased inflammation through the release of pro-inflammatory cytokines and adipokines such as leptin and visfatin all of which have been associated with osteoarthritis Locally white adipocytes in infra patellar adipose tissue are architecturally different in patients without gonarthrosis compared with those with knee osteoarthritis This difference suggests that adipocyte gene expression is directly influenced by inflammation In obese individuals there is elevated IL-6 production in brown adipose tissue Furthermore it would appear that brown adipose tissue unlike white down-regulates the inflammatory profile of macrophages
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None