Ignite Creation Date:
2024-05-06 @ 8:16 PM
Last Modification Date:
2024-10-26 @ 3:23 PM
Study NCT ID:
NCT06310785
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-05-17
First Post:
2024-01-31
Brief Title:
Esketamine Anesthesia in Thoracic Surgery
Sponsor:
Hui Xu
Organization:
Tongji Hospital
Study Overview
Official Title:
Opioid-Free Anesthesia Utilizing Esketamine for Thoracoscopic Pulmonary Nodule Surgery A Randomized Controlled Clinical Trial
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Esketamine group was induced with esketamine 05 mgkg propofol 2 mgkg and rocuronium bromide 09 mgkg Anesthesia is maintained with propofol 5 mgkgh and esketamine 05 mgkgh Anesthesia induction in the opioid group Sufentanil 05 ugkg propofol 2 mgkg rocuronium bromide 09 mgkg Anesthesia is maintained with propofol 5 mgkgh and remifentanil 1 ugkgh
Detailed Description:
Before anesthesia induction radial artery puncture and catheterization under local anesthesia for manometry and intravenous pentethylquine hydrochloride 1 mg and dexamethasone 5 mg were given Anesthesia-induced opioid group group A received intravenous sufentanil 05 ugkg and esketamine group group E received intravenous esketamine 05 mgkg Subsequently both groups were sequentially injected with intravenous propofol 2 mgkg and rocuronium bromide 09 mgkg After the onset of rocuronium bromide the left double-lumen bronchial intubation was guided by a video laryngoscope the correct position of the catheter was confirmed by bronchoscope and the anesthesia machine was connected to the anesthesia machine for mechanical ventilation after fixation with a tidal volume of 6 mLkg ideal body weight a respiratory rate of 1218 breathsmin and end-expiratory carbon dioxide partial pressure at 3540 mmHg
Intraoperative anesthesia maintenance opioid group was injected with intravenous injection of propofol 5 mgkgh and remifentanil 1 ugkgh and esketamine group was pumped with propofol 5 mgkgh and esketamine 05 mgkgh After the lateral decubitus position is set up and the lateral paravertebral nerve block T4 T6 levels 05 ropivacaine 10 ml each is performed under ultrasound guidance and the anesthesiologist is responsible for the complications and accidents that occur during the routine management of anesthesia After the operation they were given 200 mg of sugammadex sodium as an antagonistic residual muscle relaxant and after being extubated awakely they were sent to PACU for continued PCIA treatment and observation and returned to the thoracic surgery ward for further treatment after reaching the discharge criteria
Intraoperative anesthesia maintenance opioid group was injected with intravenous injection of propofol 5 mgkgh and remifentanil 1 ugkgh and esketamine group was pumped with propofol 5 mgkgh and esketamine 05 mgkgh After the lateral decubitus position is set up and the lateral paravertebral nerve block T4 T6 levels 05 ropivacaine 10 ml each is performed under ultrasound guidance and the anesthesiologist is responsible for the complications and accidents that occur during the routine management of anesthesia After the operation they were given 200 mg of sugammadex sodium as an antagonistic residual muscle relaxant and after being extubated awakely they were sent to PACU for continued PCIA treatment and observation and returned to the thoracic surgery ward for further treatment after reaching the discharge criteria
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None