Ignite Creation Date:
2024-05-06 @ 8:15 PM
Last Modification Date:
2024-10-26 @ 3:23 PM
Study NCT ID:
NCT06311396
Status:
RECRUITING
Last Update Posted:
2024-03-15
First Post:
2024-03-08
Brief Title:
Development of a Neuronal Microscope
Sponsor:
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
Organization:
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
Study Overview
Official Title:
Development of a Neuronal Microscope for Cell Characterization and Manipulation Neuronal micRoscopy for cEll Behavioral Examination and mAnipuLation
Status:
RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Hepatocellular carcinoma HCC is the most common type of primary liver cancer and is a leading cause of cancer-related death worldwide The prognosis of HCC remains poor with a 5-year survival rate of 18 Risk factors for HCC include viral infection autoimmune hepatitis chronic alcohol use or metabolic fatty liver disease obesity and diabetes mellitus
Detailed Description:
Hepatocellular carcinoma HCC is the most common type of primary liver cancer and is a leading cause of cancer-related death worldwide The prognosis of HCC remains poor with a 5-year survival rate of 18 Risk factors for HCC include viral infection autoimmune hepatitis chronic alcohol use or metabolic fatty liver disease obesity and diabetes mellitus Furthermore alterations and chronic inflammation of the microenvironment can facilitate the transformation of normal liver stem cells into precancerous tumor stem cells All these underlying pathogenic stimuli can induce a spectrum of genetic and epigenetic modifications which are involved in the cell cycle cell growth and regulation of adhesion Therefore heterogeneity and tumor priming potential arise from a combination of both endogenous and exogenous factors However current in vitro models based on conventional hepatoma and hepatocarcinoma cell lines fail to recapitulate key characteristics of tumor tissue such as three-dimensional tissue architecture cellular heterogeneity and cell-cell interactions Organoids which are 3D cellular structures generated from induced pluripotent stem cells and adult tissue-resident stem cells have recently been exploited to overcome the limitations of 2D cell culture systems emerging as powerful tools for studying human diseases Therefore organoid structures stably preserve the genetic information of autologous tissue by mimicking the pathological state of the tissue itself
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None