Ignite Creation Date:
2024-05-06 @ 8:15 PM
Last Modification Date:
2024-10-26 @ 3:23 PM
Study NCT ID:
NCT06311929
Status:
RECRUITING
Last Update Posted:
2024-05-07
First Post:
2024-03-09
Brief Title:
Precision Adjuvant Therapy After Surgery for Hepatocellular Carcinoma
Sponsor:
Chen Xiaoping
Organization:
Tongji Hospital
Study Overview
Official Title:
VETC-based Precision Adjuvant Therapy for Postoperative Hepatocellular Carcinoma a Prospective Multicenter Cohort Study
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Vessels that encapsulate tumor clusters VETC is an invasive metastatic factor in HCC independent of the epithelial mesenchyme transition EMT and VETC-positive patients have a higher rate of postoperative recurrence How to improve the prognosis of this group of patients is an urgent issue to be addressed
Detailed Description:
Previous studies have identified VETC as a new metastatic pattern independent of EMT that may be associated with immunosuppression as well as poor prognosis Multiple retrospective studies find higher rates of postoperative recurrence distant metastasis in VETC-positive patients How to improve surgical prognosis in VETC-positive patients needs to be explored There are no published studies on how to improve prognosis for this population One of our unpublished retrospective studies found that VETC-positive patients receiving PD-1 monoclonal antibody was not effective in improving prognosis However PD-1 monoclonal antibody in combination with PD-1 monoclonal antibody effectively reduced postoperative recurrence and improved prognosis in VETC-positive patients Based on our previous retrospective data this multicenter prospective cohort study was designed to further validate and explore effective therapeutics
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None