Ignite Creation Date:
2024-05-06 @ 8:15 PM
Last Modification Date:
2024-10-26 @ 3:23 PM
Study NCT ID:
NCT06311903
Status:
RECRUITING
Last Update Posted:
2024-03-15
First Post:
2024-03-09
Brief Title:
Norepinephrine in Preperiod of Hypotensive Resuscitation in Hemorrhagic Shock
Sponsor:
Tanta University
Organization:
Tanta University
Study Overview
Official Title:
Is Low Dose Norepinephrine Effective in Preperiod of Hypotensive Resuscitation in Hemorrhagic Shock
Status:
RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this work was to investigate the effects of low dose of norepinephrine in preperiod of hypotensive resuscitation in hemorrhagic shock
Detailed Description:
Hemorrhagic shock is one of the leading causes of death following trauma New fluid resuscitation concepts including hypotensive hypothermic and delayed resuscitation for uncontrolled hemorrhagic shock have been put forward and obtained a good effect both in clinical and laboratory parameters The 2019 European guideline on the management of major bleeding and coagulopathy following trauma recommends the use of norepinephrine NE for maintaining target arterial blood pressure in patients with life-threatening hypotension NE has potent α-adrenergic receptor activation activity which can stimulate α-1 adrenergic receptors on peripheral vascular smooth muscles High-dose NE may result in excessive arteriolar vasoconstriction which subsequently leads to the disorder of microcirculation and tissue hypoxia
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None