Ignite Creation Date:
2024-05-06 @ 8:15 PM
Last Modification Date:
2024-10-26 @ 3:24 PM
Study NCT ID:
NCT06318923
Status:
RECRUITING
Last Update Posted:
2024-03-20
First Post:
2024-03-12
Brief Title:
Social and Moral Cognition in Multiple Sclerosis
Sponsor:
Lille Catholic University
Organization:
Lille Catholic University
Study Overview
Official Title:
Social and Moral Cognition in Multiple Sclerosis
Status:
RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
COSMOS
Brief Summary:
Multiple Sclerosis MS is a chronic progressive disease that affects young adults aged between 20 and 40 and has a major impact on patients quality of life Cognitive disorders in MS are common affecting 40-60 of patients Among these disorders the presence of social cognition disorders is common Within social cognition the moral judgment has been an object of research in order to understand the determinants of moral decision-making how and why individuals make moral choices with regard to a set of prescriptions and social norms Compared to control subjects MS patients show a decrease in moral permissiveness as well as an increase in moral relativity and emotional reactivity Thus it would seem that MS patients issue more deontological choices lower moral permissiveness Given that these patients also exhibit empathy deficits and higher alexithymia these patterns are surprising Indeed in other clinical populations low empathic abilities and high alexithymia are linked to utilitarian rather than deontological moral judgments
The objective of this project is to analyze the process of decision-making carried out by patients during moral dilemma situations in comparison with control individuals and verify whether the presence of a positivity bias could explain the more deontological choices made by some patients Indeed some work has shown that older individuals make more deontological moral judgments than younger adults These results are also observed with young individuals when their future temporal perspectives have been experimentally constrained
The objective of this project is to analyze the process of decision-making carried out by patients during moral dilemma situations in comparison with control individuals and verify whether the presence of a positivity bias could explain the more deontological choices made by some patients Indeed some work has shown that older individuals make more deontological moral judgments than younger adults These results are also observed with young individuals when their future temporal perspectives have been experimentally constrained
Detailed Description:
Among the explanatory factors of interest motivational factors future temporal perspectives and emergence of a positivity bias as well as cognitive and affective factors by means of neuropsychological assessment and neurophysiological factors by means of electrodermal response will be investigated
From a clinical point of view a change in decision-making concerning choices with a strong emotional valence can have an impact on patients daily lives and their course of care Indeed MS patients regularly have to make crucial choices about their treatment and care A modification of decision-making patterns in these situations would represent a major challenge A good understanding of these patterns will thus contribute to the development of appropriate management procedures to mitigate the impact on patients daily lives
From a clinical point of view a change in decision-making concerning choices with a strong emotional valence can have an impact on patients daily lives and their course of care Indeed MS patients regularly have to make crucial choices about their treatment and care A modification of decision-making patterns in these situations would represent a major challenge A good understanding of these patterns will thus contribute to the development of appropriate management procedures to mitigate the impact on patients daily lives
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None