Ignite Creation Date:
2024-05-06 @ 8:15 PM
Last Modification Date:
2024-10-26 @ 3:24 PM
Study NCT ID:
NCT06317506
Status:
COMPLETED
Last Update Posted:
2024-03-19
First Post:
2024-03-12
Brief Title:
Methylation Pattern and Pain Sensation in Children With Intellectual Disability
Sponsor:
IRCCS Burlo Garofolo
Organization:
IRCCS Burlo Garofolo
Study Overview
Official Title:
Assessment of Methylation Pattern Related to Pain Sensation in Children With Intellectual Disability a Cross-sectional Study
Status:
COMPLETED
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Previous literature data indicate that children with intellectual disability ID experience more severe pain and more frequently than their cognitively healthy peers during their daily life Repeated and chronic pain exposure triggers a vicious circle of hyperalgesia and reduction of the impaired cognitive and adaptive function Furthermore these children are unable to rationalize any intervention targeted to contain potentially painful actions
Epigenetics studies mechanisms responsible for a set of modifications that regulate gene expression without altering the DNA sequence itself DNA methylation and posttranslational modification of histones are the main epigenetic mechanisms It is widely accepted that these mechanisms can be engaged by environmental experience such as early life trauma pain or addiction leading to the idea of epigenetics as a bridge between genes and environment
Several epigenetic studies evaluated genes coding proteins involved in recycling of neurotransmitters SCL6A4 in transmission of painful stimuli TRPA1 and in response to analgesics OPRM1 In particular some studies assessed TRPA1 gene coding for a cationic channel responsible for the transmission of thermal-painful sensations and SCL6A4 a serotonin-recycling transmembrane protein presents at inter-synaptic level have highlighted the importance of methylation in a pathological experience of chronic pain and anxiety disorder in the adult population Opioid receptor OPRM1 is involved in the endogenous and exogenous opioid-mediated analgesia and a recent work in a group of adolescents treated for idiopathic scoliosis highlights a link between greater pain post-surgery and methylation of this gene In this context children with ID are at greater risk of undertreatment both for the difficulty in pain recognition and for the fear of medication-adverse reactions
The epigenetic study of the aforementioned genes in children with ID associated with an evaluation of painful experiences and clinical history could help understanding a scenario that it is still complex nowadays before the eyes of parents and caregivers and healthcare workersThe finding of a different methylation pattern in children with ID could in part explain the different pain experience
Epigenetics studies mechanisms responsible for a set of modifications that regulate gene expression without altering the DNA sequence itself DNA methylation and posttranslational modification of histones are the main epigenetic mechanisms It is widely accepted that these mechanisms can be engaged by environmental experience such as early life trauma pain or addiction leading to the idea of epigenetics as a bridge between genes and environment
Several epigenetic studies evaluated genes coding proteins involved in recycling of neurotransmitters SCL6A4 in transmission of painful stimuli TRPA1 and in response to analgesics OPRM1 In particular some studies assessed TRPA1 gene coding for a cationic channel responsible for the transmission of thermal-painful sensations and SCL6A4 a serotonin-recycling transmembrane protein presents at inter-synaptic level have highlighted the importance of methylation in a pathological experience of chronic pain and anxiety disorder in the adult population Opioid receptor OPRM1 is involved in the endogenous and exogenous opioid-mediated analgesia and a recent work in a group of adolescents treated for idiopathic scoliosis highlights a link between greater pain post-surgery and methylation of this gene In this context children with ID are at greater risk of undertreatment both for the difficulty in pain recognition and for the fear of medication-adverse reactions
The epigenetic study of the aforementioned genes in children with ID associated with an evaluation of painful experiences and clinical history could help understanding a scenario that it is still complex nowadays before the eyes of parents and caregivers and healthcare workersThe finding of a different methylation pattern in children with ID could in part explain the different pain experience
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None