Ignite Creation Date:
2024-05-06 @ 8:15 PM
Last Modification Date:
2024-10-26 @ 3:24 PM
Study NCT ID:
NCT06314633
Status:
RECRUITING
Last Update Posted:
2024-03-21
First Post:
2024-03-11
Brief Title:
Socioeconomic Determinants of the Chemical Exposome and Its Genotoxic Effects in Children
Sponsor:
Institut Cancerologie de lOuest
Organization:
Institut Cancerologie de lOuest
Study Overview
Official Title:
Socioeconomic Determinants of the Chemical Exposome and Its Genotoxic Effects in Children
Status:
RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PESTIFOL
Brief Summary:
PESTIFOL will include children over 8 and under 12 years old of different socioeconomic positions SEP mostly living in the region of Pays de la Loire This approach should enable us to assess the impact of the SEP and therefore social inequalities on chemical expositions and DNA damage and to characterize which classesmixture of pollutants are major source of DNA damage The study will also address potential effects associated with geographical location on the exposome and its biological consequences
Detailed Description:
Growing evidence points to a complex influence of the exposome on health outcomes Epidemiological studies show associations between pesticides and cognitive delay and cancers Only few were conducted in children Chemical exposures differ between socioeconomic groups The more disadvantaged the group the higher are some exposures However the effect of the exposome on health is complicated to assess due to the long latencies of most diseases It is therefore important to link social and chemical exposures to immediate outcomes or molecular risk factors for human diseases There is a strong connection between DNA damage and chronic diseases such as cancers However it is difficult to attribute these risks to specific impregnations
The present study will address the impact of socioeconomic position hence social inequalities on environmental exposures and their biological consequences in children Our approach is to detect DNA damage in hair follicles and associate these measurements with pesticide detections in the hair matrix and socioeconomic position SEP
PESTIFOL will include children over 8 and under 12 years old of different socioeconomic positions SEP mostly living in the region of Pays de la Loire This approach should enable us to assess the impact of the SEP and therefore social inequalities on chemical expositions and DNA damage and to characterize which classesmixture of pollutants are major source of DNA damage The study will also address potential effects associated with geographical location on the exposome and its biological consequences
The present study will address the impact of socioeconomic position hence social inequalities on environmental exposures and their biological consequences in children Our approach is to detect DNA damage in hair follicles and associate these measurements with pesticide detections in the hair matrix and socioeconomic position SEP
PESTIFOL will include children over 8 and under 12 years old of different socioeconomic positions SEP mostly living in the region of Pays de la Loire This approach should enable us to assess the impact of the SEP and therefore social inequalities on chemical expositions and DNA damage and to characterize which classesmixture of pollutants are major source of DNA damage The study will also address potential effects associated with geographical location on the exposome and its biological consequences
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None