Ignite Creation Date:
2024-05-06 @ 8:14 PM
Last Modification Date:
2024-10-26 @ 3:23 PM
Study NCT ID:
NCT06304298
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-03-12
First Post:
2023-05-24
Brief Title:
NLR and PLR Levels Following iPACK Block in Knee Arthroplasty
Sponsor:
Poznan University of Medical Sciences
Organization:
Poznan University of Medical Sciences
Study Overview
Official Title:
The Neutrophil-to-lymphocyte Ratio NLR and Platelet-to-lymphocyte Ratio PLR Levels Following iPACK Block in Knee Arthroplasty a Randomized Controlled Trial
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Effect of iPACK block on NLR and PLR following knee arthroplasty
Detailed Description:
The NLR is a sensitive indicator of inflammation confirmed in numerous studies and has a predictive and prognostic value NLR is a cheap simple fast-acting readily available stress and inflammation parameter with high sensitivity and low specificity Dynamic changes in the NLR precede the clinical state for several hours and may alert clinicians early about the ongoing pathological process NLR is a new promising marker of cellular immune activation an important indicator of stress and systemic inflammation It opens a new dimension for clinical medicine to understand better the biology of inflammation the linkage and antagonism between innate and adaptive immunity and its clinical consequences for health and disease
NLR is affected not only by surgical trauma but also by the method of anesthesia In recent years the influence of regional anesthesiology on reducing the inflammatory response after surgical procedures has been emphasized However there have been very few studies evaluating the effect of various methods of anesthesia on the NLR
This is the first study to investigate the effect of regional anesthesia on the NLR and PLR in patients undergoing knee replacement surgery
NLR is affected not only by surgical trauma but also by the method of anesthesia In recent years the influence of regional anesthesiology on reducing the inflammatory response after surgical procedures has been emphasized However there have been very few studies evaluating the effect of various methods of anesthesia on the NLR
This is the first study to investigate the effect of regional anesthesia on the NLR and PLR in patients undergoing knee replacement surgery
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None