Ignite Creation Date:
2024-05-06 @ 8:14 PM
Last Modification Date:
2024-10-26 @ 3:23 PM
Study NCT ID:
NCT06304948
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-03-26
First Post:
2024-03-05
Brief Title:
The Link Between Human Cytomegalovirus Gene Expression and Glutamate Level in MigraineRelation to Vitamin D Deficiency
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
The Link Between Human Cytomegalovirus Gene Expression and Glutamate Levels in Migraine Relationship to the Vit D Deficiency
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
1 To correlate serum 25OH-vitamin D level with duration frequency and severity of migraine headache attacks
2 To evaluate the relationship between the serum level of vitamin D and other indices in patients with migraine
3 To correlate the serum level of glutamate with gene expression of in migraine
2 To evaluate the relationship between the serum level of vitamin D and other indices in patients with migraine
3 To correlate the serum level of glutamate with gene expression of in migraine
Detailed Description:
According to the report of global burden of disease GBD 2016 migraine headache has been established as the leading disability cause in the globe among under 50 years old 1 It has been estimated that migraine affects about 11 of adults with a major impact on those aged between 25 to 55 years which consequently lead to the high headache burden on individuals communities health care systems and societies Migraine is 2-3 times more common in women than in men Migraine attacks are usually more prolonged with higher intensity and more disability among females
Current pharmacological treatments for migraine demonstrated limited efficacy in some patients and commonly lead to some adverse events such as weight reduction or weight gain fatiguesleepiness sweating night dreams gastrointestinal upset and hypotension or reduced concentration Novel therapeutic approaches of nutritional agents have become the promising strategies to alleviate symptoms of migraine Vitamin D one of the dietary agents has revealed some potential in managing pain and migraine
Cytomegalovirus CMV contamination is one of the clinically most critical irresistible complications of solid-organ transplantation CMV disease characterized as a critical rise within the titer of CMV-specific antibodies happens in 44 to 85 of kidney heart and liver transplant recipients - basically within the to begin with 3 months post transplantation when immunosuppression is most intense CMV malady shows in transplant beneficiaries essentially within the organ transplanted with the chance of successive dispersal and disability of other organs such as the central-nervous system eye and urogenital- or gastrointestinal tract Additionally dynamic CMV disease could be a noteworthy autonomous indicator of intense unite dismissal and event of artful contaminations
Join brokenness and dismissal are related with vitamin D VD lack In patients with end-stage organ disappointment anticipating transplant VD lacking and lack are greatly common Inadequately levels of vitamin D metabolites 25-hydroxyvitamin D 25OHD3 and 125-hydroxyvitamin D 1a25_ Dihydroxyvitamin D3 have been detailed for patients with terminal congestive heart disappointment pneumonic infection liver disappointment 5 and incessant kidney illness
in the past few years there has been increasing interest in the complex interplay between vitamin D and infectious pathogens 7 Vitamin D supplementation is beneficial for patients with HIV hepatitis C virus Chlamydia spp or mycobacterial infection A significant reduction in the risk of CMV infection and disease by vitamin D supplementation would be highly attractive because of a high therapeutic index of vitamin D the ease of application oral solutions and added benefits such as improved musculoskeletal health Contrary to expectation we found that CMV infection interferes with the vitamin D system of mammalian cells
CMV infection downregulated vitamin D receptor expression and this downregulation was specific for CMV and was not observed for other common human viruses This observation may have far-reaching virological immunological and clinical implication
The aim of the present study was to assess a possible effect of migraine in patients with CMV infection on vit D levels and Glutamate levels to combine existing knowledge about the role of glutamate in migraine pathogenesis along with information on nutrients that are protective against glutamate excitotoxicity and then end with a proposed dietary treatment for migraine management
There is an obvious gap between our understanding of migraines and the dietary strategies which have been administered so far since dietary nutrients are often studied separately and no specific diet for migraine has been developed However the beneficial effects of the low glutamate diet on widespread chronic pain disorders appear to have overlapping mechanistic effects and additionally is some preliminary evidence supporting an effect on migraine Thus further research on this dietary strategy in migraine is warranted
Current pharmacological treatments for migraine demonstrated limited efficacy in some patients and commonly lead to some adverse events such as weight reduction or weight gain fatiguesleepiness sweating night dreams gastrointestinal upset and hypotension or reduced concentration Novel therapeutic approaches of nutritional agents have become the promising strategies to alleviate symptoms of migraine Vitamin D one of the dietary agents has revealed some potential in managing pain and migraine
Cytomegalovirus CMV contamination is one of the clinically most critical irresistible complications of solid-organ transplantation CMV disease characterized as a critical rise within the titer of CMV-specific antibodies happens in 44 to 85 of kidney heart and liver transplant recipients - basically within the to begin with 3 months post transplantation when immunosuppression is most intense CMV malady shows in transplant beneficiaries essentially within the organ transplanted with the chance of successive dispersal and disability of other organs such as the central-nervous system eye and urogenital- or gastrointestinal tract Additionally dynamic CMV disease could be a noteworthy autonomous indicator of intense unite dismissal and event of artful contaminations
Join brokenness and dismissal are related with vitamin D VD lack In patients with end-stage organ disappointment anticipating transplant VD lacking and lack are greatly common Inadequately levels of vitamin D metabolites 25-hydroxyvitamin D 25OHD3 and 125-hydroxyvitamin D 1a25_ Dihydroxyvitamin D3 have been detailed for patients with terminal congestive heart disappointment pneumonic infection liver disappointment 5 and incessant kidney illness
in the past few years there has been increasing interest in the complex interplay between vitamin D and infectious pathogens 7 Vitamin D supplementation is beneficial for patients with HIV hepatitis C virus Chlamydia spp or mycobacterial infection A significant reduction in the risk of CMV infection and disease by vitamin D supplementation would be highly attractive because of a high therapeutic index of vitamin D the ease of application oral solutions and added benefits such as improved musculoskeletal health Contrary to expectation we found that CMV infection interferes with the vitamin D system of mammalian cells
CMV infection downregulated vitamin D receptor expression and this downregulation was specific for CMV and was not observed for other common human viruses This observation may have far-reaching virological immunological and clinical implication
The aim of the present study was to assess a possible effect of migraine in patients with CMV infection on vit D levels and Glutamate levels to combine existing knowledge about the role of glutamate in migraine pathogenesis along with information on nutrients that are protective against glutamate excitotoxicity and then end with a proposed dietary treatment for migraine management
There is an obvious gap between our understanding of migraines and the dietary strategies which have been administered so far since dietary nutrients are often studied separately and no specific diet for migraine has been developed However the beneficial effects of the low glutamate diet on widespread chronic pain disorders appear to have overlapping mechanistic effects and additionally is some preliminary evidence supporting an effect on migraine Thus further research on this dietary strategy in migraine is warranted
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None