Ignite Creation Date:
2024-05-06 @ 8:13 PM
Last Modification Date:
2024-10-26 @ 3:23 PM
Study NCT ID:
NCT06296394
Status:
RECRUITING
Last Update Posted:
2024-07-03
First Post:
2024-02-28
Brief Title:
Health Outcomes of Parents With Cystic Fibrosis-Aim 2
Sponsor:
University of Pittsburgh
Organization:
University of Pittsburgh
Study Overview
Official Title:
Health Outcomes of Parents With Cystic Fibrosis-Aim 2
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
HOPeCF
Brief Summary:
The goal of this observational prospective study is to determine the health impact of parenthood on United States US people with CF in the era of CF transmembrane regulator protein CFTR modulators The investigators will collect physical and mental health data to comprehensively evaluate the impact of parenthood in CF with widespread highly effective CFTR modulator use The main hypotheses this study aims to examine are
H1 Parents with CF and moderate-to-severe depression have more rapid change in ppFEV1 percent predicted forced expiratory volume in one second versus those with mild or no depression
H2 Parents with CF who have more parental responsibility andor stress have more rapid ppFEV1 percent predicted forced expiratory volume in one second change than those with less responsibilitystress
H3 Parents using CFTR modulators have decreased ppFEV1 percent predicted forced expiratory volume in one second change versus those not using CFTR modulators
Participants will complete quarterly surveys during the first year of parenthood and biannual surveys thereafter using the computer-based survey system on an iPad protected for infection control or via personal device or computer via emailed survey link
H1 Parents with CF and moderate-to-severe depression have more rapid change in ppFEV1 percent predicted forced expiratory volume in one second versus those with mild or no depression
H2 Parents with CF who have more parental responsibility andor stress have more rapid ppFEV1 percent predicted forced expiratory volume in one second change than those with less responsibilitystress
H3 Parents using CFTR modulators have decreased ppFEV1 percent predicted forced expiratory volume in one second change versus those not using CFTR modulators
Participants will complete quarterly surveys during the first year of parenthood and biannual surveys thereafter using the computer-based survey system on an iPad protected for infection control or via personal device or computer via emailed survey link
Detailed Description:
The investigators will follow 146 new parents of children 5 years of age at 18 participating US adult CF centers to assess the primary outcome of percent predicted forced expiratory volume in one second ppFEV1 up to 5 years after becoming a parent A prospective approach will capture the immediate and long-term impact of the use of the highly effective CFTR modulator ETI elexacaftortezacaftorivacaftor by 90 percent of US adults with CF By combining objective health measures and participant surveys the investigators can comprehensively assess the psychosocial impacts of parenthood and explore the interplay between the parenting role and physical and mental health The investigators anticipate identifying modifiable factors that may ameliorate negative health impacts of parenthood The investigators will conduct hypothesis-generating semi-structured dyadic interviews with a subset of parents and their key supports partnerfamilyfriend to inform future interventions The investigators have selected qualitative methodology to avoid preconceived theorieshypotheses
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 1R01HL161164-01A1 | NIH | None | None |
| KAZMER22A0 | OTHER_GRANT | Cystic Fibrosis Foundation | httpsreporternihgovquickSearch1R01HL161164-01A1 |