Ignite Creation Date:
2024-05-06 @ 8:12 PM
Last Modification Date:
2024-10-26 @ 3:23 PM
Study NCT ID:
NCT06297538
Status:
RECRUITING
Last Update Posted:
2024-03-07
First Post:
2024-02-22
Brief Title:
Parkinsons Disease and Gamma-transcranial Alternating Current Stimulation
Sponsor:
Neuromed IRCCS
Organization:
Neuromed IRCCS
Study Overview
Official Title:
Targeting the Motor Cortex in Parkinsons Disease by Gamma-transcranial Alternating Current Stimulation Pathophysiological and Therapeutic Implications
Status:
RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Cortical-basal ganglia gamma oscillations are pathologically reduced in Parkinsons disease PD and the plasticity of the primary motor cortex M1 is impaired Enhancing gamma oscillations through transcranial alternating current stimulation tACS a non-invasive neurophysiological tool that modulates cortical rhythms can restore this alteration However whether tACS-related normalization of M1 plasticity results in positive clinical effects is unknown Motor learning is also impaired in PD and gamma oscillations play a relevant role in different forms of learning in humans Nevertheless whether motor learning abnormalities relate to reduced gamma oscillations in PD is another unclear issue It can be hypothesized that gamma oscillations impairment in M1 contributes to altered motor control plasticity and learning in PD Accordingly in this project the authors intend to test whether gamma-tACS on M1 in PD patients ameliorates motor performance and learning as objectively assessed with kinematic techniques
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None