Ignite Creation Date:
2024-05-06 @ 8:12 PM
Last Modification Date:
2024-10-26 @ 3:22 PM
Study NCT ID:
NCT06290453
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-03-04
First Post:
2024-02-20
Brief Title:
The Regulatory Role of miRNA 27 Follistatin Like Protein-1 Gene in Multiple Scelerosis
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
The Regulatory Role of miRNA 27 and Follistatin Like Protein-1 Gene in the Pathophysiology of Multiple Sclerosis Patients
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Multiple sclerosis MS is a neurodegenerative disease characterized by demyelination of the central nervous system Young women between the ages of 20 and 40 are primarily targeted by this disabling disorder Till now there are no sufficient mechanisms to explain the pathophysiology of multiple sclerosis
Detailed Description:
Neuroinflammation has been implicated in the initiation and progression of several central nervous system CNS disorders including multiple sclerosis Microglia and astrocytes are essential in neural development maintenance of synaptic connections and homeostasis in a healthy brain
Recent researchers have discovered that microRNAs miRNAs contribute to the pathophysiology of MS primarily influencing glial cells and the immune cells in the periphery In recent years miRNAs have become more prevalent as inflammation and demyelination process regulators in MS
miRNAs are naturally occurring non-coding RNA molecules 21-25 nucleotides miRNAs play a part in the post-transcriptional regulation of gene expression and silencing of RNA miRNAs have been discovered to control some physiological processes as apoptosis proliferation differentiation and development
Measurement of circulating miRNAs in MS patients peripheral blood is one of the promising approaches as it can be a non-invasive tool to explain its pathogenesis miRNAs are remarkably stable in bodily fluids and are relatively simple to collect and quantify Moreover a novel approach to therapy may be based on methods that regulate the activity of miRNAs
Several miRNAs particularly miR-27 have been reportedly involved in regulating myelination in the central nervous system However the role of micro RNAs in generation or progression of MS remains elusive
Follistatin-like protein-1 FSTL1 was first identified as a transforming growth factor β1-inducible protein In the last decade FSTL1 has been identified as a novel inflammatory protein FSTL1 is a glycoprotein rich in cysteine SPARC family FSTL1 is elevated in various inflammatory conditions and decreased during treatment
Moreover a variety of studies suggest that targeting of FSTL1 may be useful in the treatment of diseases in which inflammation plays a central role Recent studies revealed a substantial connection between FSTL1 and micro-RNA 27 levels and demonstrated that the regulatory effects of miR-27 in some inflammatory conditions may be exerted by targeting FSTL1
This study aims to investigate the expression patterns of miR-27 and Follistatin like 1 gene in peripheral blood samples of MS patients As we hypothesize that miR-27 and its target gene FSTL1 may serve important roles in the pathogenesis of MS
Recent researchers have discovered that microRNAs miRNAs contribute to the pathophysiology of MS primarily influencing glial cells and the immune cells in the periphery In recent years miRNAs have become more prevalent as inflammation and demyelination process regulators in MS
miRNAs are naturally occurring non-coding RNA molecules 21-25 nucleotides miRNAs play a part in the post-transcriptional regulation of gene expression and silencing of RNA miRNAs have been discovered to control some physiological processes as apoptosis proliferation differentiation and development
Measurement of circulating miRNAs in MS patients peripheral blood is one of the promising approaches as it can be a non-invasive tool to explain its pathogenesis miRNAs are remarkably stable in bodily fluids and are relatively simple to collect and quantify Moreover a novel approach to therapy may be based on methods that regulate the activity of miRNAs
Several miRNAs particularly miR-27 have been reportedly involved in regulating myelination in the central nervous system However the role of micro RNAs in generation or progression of MS remains elusive
Follistatin-like protein-1 FSTL1 was first identified as a transforming growth factor β1-inducible protein In the last decade FSTL1 has been identified as a novel inflammatory protein FSTL1 is a glycoprotein rich in cysteine SPARC family FSTL1 is elevated in various inflammatory conditions and decreased during treatment
Moreover a variety of studies suggest that targeting of FSTL1 may be useful in the treatment of diseases in which inflammation plays a central role Recent studies revealed a substantial connection between FSTL1 and micro-RNA 27 levels and demonstrated that the regulatory effects of miR-27 in some inflammatory conditions may be exerted by targeting FSTL1
This study aims to investigate the expression patterns of miR-27 and Follistatin like 1 gene in peripheral blood samples of MS patients As we hypothesize that miR-27 and its target gene FSTL1 may serve important roles in the pathogenesis of MS
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None