Ignite Creation Date:
2024-05-06 @ 8:12 PM
Last Modification Date:
2024-10-26 @ 3:22 PM
Study NCT ID:
NCT06295666
Status:
COMPLETED
Last Update Posted:
2024-03-06
First Post:
2024-01-02
Brief Title:
Gingival Crevicular Fluid GCF Bactericidal Permeability Protein BPI and Interleukin IL-1 Beta
Sponsor:
Akdeniz University
Organization:
Akdeniz University
Study Overview
Official Title:
Gingival Crevicular FluidGCF Bactericidal Permeability Protein BPI and InterleukinIL-1 Beta Levels and Relationship With Periodontal Disease
Status:
COMPLETED
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Objective The aim of this study is to determine the amounts of BPI Bactericidal permeability protein and interleukin-1beta IL-1β in gingival fluid samples obtained from individuals with periodontally healthy and periodontal disease to compare these amounts between study groups and to evaluate their relationship with clinical parameters In cases where clinical parameters increase IL-1β amounts also increase significantly The amount of IL-1β in individuals with periodontal disease is significantly higher compared to healthy individuals There is positive correlation between BPI and clinical parameters The amount of BPI in individuals with periodontal disease is significantly higher than in healthy individuals More studies are needed to better understand the importance and therapeutic effect of BPI in periodontitis
Detailed Description:
Systemically healthy and non-smoking participants were included in the study The study groups included a total of 100 participants 50 of whom were periodontally healthy healthy group and 50 with periodontal disease periodontitis group The clinical parameters of plaque index PI gingival index GI and pocket depth PD clinical attachment level CAL and bleeding on probing BOP were measured
The gingival fluid samples were taken in the direction of the paper strip and ELISA method was used for their analysis A positive statistically significant relationship was found between IL-1β levels and all clinical parameters PI GI PD CAL BOP p001 Likewise there is a positive and significant relationship between BPI levels and clinical parameters p001
There is a statistically significant positive correlation between GCF volume and clinical parameters PI r 0722 GI r 0740 PD r 0742 CAL r 0751 and BOP r 0752 p 001 In the comparison between the groups it is seen that both IL-1β and BPI levels were statistically significantly higher in the periodontitis group compared to the healthy group p 0001
The gingival fluid samples were taken in the direction of the paper strip and ELISA method was used for their analysis A positive statistically significant relationship was found between IL-1β levels and all clinical parameters PI GI PD CAL BOP p001 Likewise there is a positive and significant relationship between BPI levels and clinical parameters p001
There is a statistically significant positive correlation between GCF volume and clinical parameters PI r 0722 GI r 0740 PD r 0742 CAL r 0751 and BOP r 0752 p 001 In the comparison between the groups it is seen that both IL-1β and BPI levels were statistically significantly higher in the periodontitis group compared to the healthy group p 0001
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None