Ignite Creation Date:
2024-05-06 @ 8:12 PM
Last Modification Date:
2024-10-26 @ 3:22 PM
Study NCT ID:
NCT06294145
Status:
RECRUITING
Last Update Posted:
2024-05-17
First Post:
2024-02-27
Brief Title:
Effects of a Wellbeing Intervention on Inflammation Through Reward and Threat Processes
Sponsor:
University of California Los Angeles
Organization:
University of California Los Angeles
Study Overview
Official Title:
Effects of a Wellbeing Intervention on Inflammation Through Reward and Threat Processes
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
SAVOR
Brief Summary:
This study aims to evaluate how savoring influences reward and threat processes and downstream inflammation Savoring is designed to enhance positive affect which may blunt stress responses and reduce downstream inflammation The investigators aim to examine changes in the brain following the savoring intervention The investigators are particularly interested in changes in brain activity that are correlated with changes in inflammation-related markers in the blood In this single-armed pilot trial the investigators will assess how savoring alters reactivity to rewarding and threatening experiences and then examine related changes in downstream inflammation The investigators intend to recruit 20 undergraduate students to complete a 7-week standardized savoring intervention Participants will complete brain scans daily diaries questionnaires a behavioral task and blood collection at pre- and post-intervention assessments
Detailed Description:
Interventions that enhance wellbeing have the power to improve both mental and physical health but the exact mechanisms through which they confer these benefits remain unclear Inflammation may be a key pathway there is substantial evidence that both eudaimonic and hedonic wellbeing are associated with lower levels of inflammatory activity Cole et al 2015 Brouwers et al 2013 Ironson et al 2018 which may in turn have beneficial effects on health Furman et al 2019 However wellbeing may influence inflammation through multiple mechanisms including reward and threat processes Dutcher et al 2021 Eisenberger Cole 2012 Identifying the mediating circuitry will help guide the development of targeted interventions able to protect against inflammation-related diseases like depression However reward and threat processes have yet to be examined as potential mediators of wellbeings effects on inflammation and health
This study aims to evaluate how wellbeing may influence reward and threat processing and downstream inflammation using a novel savoring intervention Positive Affect Treatment PATCraske et al 2016 Craske et al 2019 Savoring is a common component of many positive psychology and mindfulness interventions that involves cultivating sustained enjoyment of positive experiences It is designed to enhance reward processing which should in turn decrease threat processing and lead to blunted stress responses and reduced downstream inflammation Eisenberger Cole 2012 The investigators will collect daily diaries neuroimaging and questionnaires pre- and post-intervention to assess wellbeing reactivity to social and nonsocial rewarding experiences and buffering of stressful experiences in a single-armed pilot trial of 20 participants from the diverse undergraduate population at UCLA The investigators will also collect blood samples to facilitate examination of immunological biomarkers
By examining reward and threat processing at multiple levels inside and outside of the laboratory the investigators aim to strengthen the understanding of how wellbeing alters the way humans perceive and interact with the world Increased reward reactivity and decreased threat reactivity may be two key mechanisms through which wellbeing impacts stress physiology and downstream inflammation The investigators will examine if the savoring intervention is associated with decreases in circulating inflammatory biomarkers such as interleukin-6 IL-6 and C-Reactive Protein CRP as well as reductions in pro-inflammatory gene expression This study will also clarify whether savoring is an active ingredient driving the mental and physical benefits of many positive psychology and mindfulness interventions
This study aims to evaluate how wellbeing may influence reward and threat processing and downstream inflammation using a novel savoring intervention Positive Affect Treatment PATCraske et al 2016 Craske et al 2019 Savoring is a common component of many positive psychology and mindfulness interventions that involves cultivating sustained enjoyment of positive experiences It is designed to enhance reward processing which should in turn decrease threat processing and lead to blunted stress responses and reduced downstream inflammation Eisenberger Cole 2012 The investigators will collect daily diaries neuroimaging and questionnaires pre- and post-intervention to assess wellbeing reactivity to social and nonsocial rewarding experiences and buffering of stressful experiences in a single-armed pilot trial of 20 participants from the diverse undergraduate population at UCLA The investigators will also collect blood samples to facilitate examination of immunological biomarkers
By examining reward and threat processing at multiple levels inside and outside of the laboratory the investigators aim to strengthen the understanding of how wellbeing alters the way humans perceive and interact with the world Increased reward reactivity and decreased threat reactivity may be two key mechanisms through which wellbeing impacts stress physiology and downstream inflammation The investigators will examine if the savoring intervention is associated with decreases in circulating inflammatory biomarkers such as interleukin-6 IL-6 and C-Reactive Protein CRP as well as reductions in pro-inflammatory gene expression This study will also clarify whether savoring is an active ingredient driving the mental and physical benefits of many positive psychology and mindfulness interventions
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| U24AG072699 | NIH | None | httpsreporternihgovquickSearchU24AG072699 |