Ignite Creation Date:
2024-05-06 @ 8:11 PM
Last Modification Date:
2024-10-26 @ 3:22 PM
Study NCT ID:
NCT06283368
Status:
COMPLETED
Last Update Posted:
2024-03-01
First Post:
2024-02-21
Brief Title:
Red Blood Cell Distributions RDW RDW-CW and Lymphocyte Monocyte Ratios LMR for the Malignant Thyroid Nodules
Sponsor:
Kahramanmaras Sutcu Imam University
Organization:
Kahramanmaras Sutcu Imam University
Study Overview
Official Title:
Red Blood Cell Distributions RDW RDW-CW and Lymphocyte Monocyte Ratios LMR for the Detection of Malignant Thyroid Nodules in the Preoperative Period
Status:
COMPLETED
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Thyroid surgery is the most common type of surgery among endocrine surgeries This surgery is performed for patients with suspected malignancy patients diagnosed with malignancy and toxic nodular goiter In addition to vocal cord injury which is the most important complication of thyroid surgery hypocalcemia due to hypoparathyroidism and surgical wound complications such as hematoma and fistula can also be observed and malignancy surgery increases the risk of recurrent laryngeal nerve injury Therefore it is important to differentiate these groups using non-invasive methods before surgery
Tumor-related inflammation is activated as a result of bone marrow and inflammation induced by malignancies Insufficiently controlled or uncontrolled inflammatory activity may be responsible for malignant transformation Lymphocyte monocyte ratio and red blood cell distribution are parameters RDW RDW-CW previously studied in terms of cancers
Our aim in this study is to reveal the RDW RDW-CW and LMR calculated from complete blood count parameters in the preoperative period as an indicator of malignant inflammatory response in a non-invasive and inexpensive way before surgery or biopsy is performed to distinguish nodular goiter and thyroid malignancy
Tumor-related inflammation is activated as a result of bone marrow and inflammation induced by malignancies Insufficiently controlled or uncontrolled inflammatory activity may be responsible for malignant transformation Lymphocyte monocyte ratio and red blood cell distribution are parameters RDW RDW-CW previously studied in terms of cancers
Our aim in this study is to reveal the RDW RDW-CW and LMR calculated from complete blood count parameters in the preoperative period as an indicator of malignant inflammatory response in a non-invasive and inexpensive way before surgery or biopsy is performed to distinguish nodular goiter and thyroid malignancy
Detailed Description:
Thyroid surgery patients older than 18 who were operated on at the Department of General Surgery of Kahramanmaras Sutcu Imam University between January 2016 and January 2021 for nodular goiter and thyroid malignancy surgical procedures include bilateral total thyroidectomy unilateral total thyroidectomy bilateral subtotal thyroidectomy unilateral subtotal thyroidectomy bilateral near total completion thyroidectomy for recurrent cases Patients will be evaluated as malignant patients and patients with benign goiter diseases according to the pathology results Lymphocyte-monocyte ratios will be calculated manually by recording lymphocyte numbers monocyte numbers and red blood cell distribution volumes RDW and RDW-CW in the routine complete blood count values of the patients in the preoperative period Patient data will be accessed from the preoperative laboratory and postoperative pathology results recorded in patient epicrisis forms and the computer system
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None