Ignite Creation Date:
2024-05-06 @ 8:11 PM
Last Modification Date:
2024-10-26 @ 3:22 PM
Study NCT ID:
NCT06283433
Status:
RECRUITING
Last Update Posted:
2024-02-28
First Post:
2023-10-30
Brief Title:
A Dried Blood Spot Sampling Method for Vancomycin and Creatinine Monitoring for OPAT
Sponsor:
Erasmus Medical Center
Organization:
Erasmus Medical Center
Study Overview
Official Title:
A Dried Blood Spot Sampling Method for Vancomycin and Creatinine Monitoring Effectiveness Demonstrated in Outpatient Parenteral Antibiotic Therapy Service
Status:
RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ADVANCEDOPAT
Brief Summary:
The Outpatient Parenteral Antibiotic Therapy OPAT service consists of providing antimicrobial therapy through parenteral infusion without hospitalization This service is provided to stable patients otherwise ready for hospital discharge Generally the clinical monitoring for this patient population is minimal However clinical monitoring of vancomycin an antibiotic widely used during OPAT can be intensive primarily due to therapeutic drug monitoring To ensure optimal treatment and minimize nephrotoxicity and microbial resistance TDM and monitoring of serum creatinine levels are crucial during vancomycin therapy TDM of vancomycin with OPAT presents a challenge for patients who must frequently travel to blood sampling facilities or the hospital for measurements An alternative sampling method for TDM is the dried blood spot DBS method which involves collecting a small drop of capillary blood from a finger prick onto filter paper By implementing the DBS sampling method the amount of outpatient visits regarding vancomycin treatment in OPAT can be reduced Furthermore the addition of measuring a biochemical parameter such as renal function with serum creatinine could lead to even less outpatient visits during OPAT To date studies investigating the effectiveness of DBS sampling of vancomycin and creatinine in terms of reducing outpatient visits have not yet been conducted in the OPAT population
Detailed Description:
The use of vancomycin in OPAT services is widespread however a drawback of its use is the need for laboratory monitoring of the vancomycin concentration which requires patients to travel to a blood sampling facility or the hospital for blood sampling At most hospitals at least one or two blood samples per week are obtained for vancomycin drug monitoring from a patient in OPAT service receiving vancomycin Conventional blood sampling involves an invasive procedure of drawing blood from a vene through a venipuncture this is performed by a qualified health care worker at a blood drawing facility often performed by a nurse in the hospital Besides the burden for the patient to travel to a blood sampling facility the costs also have to be taken into account contributing to a higher cost for OPAT services
The hospital pharmacy laboratory of Erasmus University Medical Center has developed and clinically validated a dried blood spot DBS assay for measuring vancomycin and creatinine ADVANCED study The use of dried blood spot collection to quantify drug concentrations is an innovative technique that requires only a simple finger prick instead of an invasive venipuncture Consequently this is less painful and stressful for the patient than conventional blood sampling DBS can be performed by taking a low-volume finger prick samples 10 to 20 μl on filter paper Finger samples can be taken and stored with a desiccant without the need for processing and freezing of plasma A small-diameter disc or chad can be subsequently punched out from the filter paper and the drug can be eluted into a liquid matrix prior to a liquid chromatography-mass spectrometry LC-MS assay The main benefit of DBS sampling is that it allows for the ease of self-sampling at home DBS offers several other practical advantages over conventional plasma sampling These advantages include lower sample volume requirements simplified collection techniques and less restrictive transport and storage conditions
DBS sampling eliminates the need to travel to a sampling facility as no healthcare professionals are involved in the sampling process To date studies investigating the effectiveness of DBS sampling in terms of reducing outpatient visits have not been conducted in the OPAT population OPAT is provided for patients who are stable and healthy enough to leave the hospital and clinical monitoring of these patient population is minimal However clinical monitoring of vancomycin therapy during OPAT is intensive due to TDM of vancomycin Most protocols oblige at least once weekly TDM of vancomycin which contributes to outpatient visits By implementing DBS sampling the investigators hypothesize that the number of outpatient visits regarding vancomycin therapy in OPAT services can be reduced Furthermore this effectiveness may increase when a biochemical parameter such as renal function parameter ie creatinine are measured along with drug concentrations leading to even less outpatient visits the benefit of this has not been investigated yet
The hospital pharmacy laboratory of Erasmus University Medical Center has developed and clinically validated a dried blood spot DBS assay for measuring vancomycin and creatinine ADVANCED study The use of dried blood spot collection to quantify drug concentrations is an innovative technique that requires only a simple finger prick instead of an invasive venipuncture Consequently this is less painful and stressful for the patient than conventional blood sampling DBS can be performed by taking a low-volume finger prick samples 10 to 20 μl on filter paper Finger samples can be taken and stored with a desiccant without the need for processing and freezing of plasma A small-diameter disc or chad can be subsequently punched out from the filter paper and the drug can be eluted into a liquid matrix prior to a liquid chromatography-mass spectrometry LC-MS assay The main benefit of DBS sampling is that it allows for the ease of self-sampling at home DBS offers several other practical advantages over conventional plasma sampling These advantages include lower sample volume requirements simplified collection techniques and less restrictive transport and storage conditions
DBS sampling eliminates the need to travel to a sampling facility as no healthcare professionals are involved in the sampling process To date studies investigating the effectiveness of DBS sampling in terms of reducing outpatient visits have not been conducted in the OPAT population OPAT is provided for patients who are stable and healthy enough to leave the hospital and clinical monitoring of these patient population is minimal However clinical monitoring of vancomycin therapy during OPAT is intensive due to TDM of vancomycin Most protocols oblige at least once weekly TDM of vancomycin which contributes to outpatient visits By implementing DBS sampling the investigators hypothesize that the number of outpatient visits regarding vancomycin therapy in OPAT services can be reduced Furthermore this effectiveness may increase when a biochemical parameter such as renal function parameter ie creatinine are measured along with drug concentrations leading to even less outpatient visits the benefit of this has not been investigated yet
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None