Ignite Creation Date:
2024-05-06 @ 8:10 PM
Last Modification Date:
2024-10-26 @ 3:22 PM
Study NCT ID:
NCT06279845
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-03-04
First Post:
2024-02-18
Brief Title:
A Clinical Cohort Study on the Pathogen Spectrum of Hepatic Virus-caused Cirrhosis Complicated With Infection
Sponsor:
Zhejiang University
Organization:
Zhejiang University
Study Overview
Official Title:
A Multicenter Prospective Clinical Cohort Study on the Pathogen Spectrum of Hepatic Virus-caused Cirrhosis Complicated With Infection
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this observational study is to expound the population and characteristics of pathogenic microorganisms with co-infection draw the pedigree of pathogenic microorganisms and evaluate its influence on disease outcome in patients with hepatic virus-caused cirrhosis The main questions it aims to answer are
Describe the populations and characteristics of pathogenic microorganisms responsible for co-infections in patients with hepatic virus-caused cirrhosis
Map the spectrum of pathogenic microorganisms and evaluate their impact on disease regression
Describe the populations and characteristics of pathogenic microorganisms responsible for co-infections in patients with hepatic virus-caused cirrhosis
Map the spectrum of pathogenic microorganisms and evaluate their impact on disease regression
Detailed Description:
Cirrhosis is a chronic progressive disease caused by different etiological factors and characterized by diffuse hepatocellular degeneration and necrosis abnormal regeneration of hepatocytes intrahepatic neovascularization massive proliferation of hepatic fibrotic tissues and pseudofollicular formation The number of patients with liver disease in China is about 300 million and the number of deaths from cirrhosis accounts for 11 of the global deaths from cirrhosis Its etiology is diverse and hepatitis due to hepatophilic virus infection is still the main cause in China A recent study by scholars on 11861 patients hospitalized for the first time due to liver cirrhosis in 50 hospitals in China showed that among the causes of liver cirrhosis in China HBV infection accounted for 7115 and HCV infection accounted for 812 About two-thirds of patients with cirrhosis and extrahepatic organ failure suffer from sepsis Infections increase the risk of death in patients with cirrhosis and reports have shown that these patients are hospitalized for twice as long as patients without cirrhotic sepsis and have a hospital mortality rate of up to 50 This study focuses on the impact of secondary infections on the clinical prognosis of cirrhosis and proposes to establish a prospective multicenter clinical cohort of secondary infections in cirrhosis map infection pathogens correlate the characteristics of the underlying immune status with the pathogen profiles of secondary infections and set up an early warning system of secondary infection surveillance with the aim of early prevention and early recognition of secondary infections and improvement of prognosis for patients with liver cirrhosis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None