Ignite Creation Date:
2024-05-06 @ 8:09 PM
Last Modification Date:
2024-10-26 @ 3:21 PM
Study NCT ID:
NCT06271434
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-03-18
First Post:
2024-02-14
Brief Title:
Effects of Krill Oil on Intestinal Integrity Markers in Elite Rowers
Sponsor:
Poznan University of Physical Education
Organization:
Poznan University of Physical Education
Study Overview
Official Title:
Krill Oil Supplementation and Its Effect on Intestinal Permeability Markers in Elite Rowers
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The study aims to check the influence of krill oil on markers of intestinal injury and intoxication
Research group the research will be conducted in a homogeneous group of professional rowers N30 all competitors qualified for the Polish Youth Rowing Team aged 18 - 24 The sample size was confiremed in statistical analyses
Rowing performance test will be conducted at the beginning and at the end of the training camp Participants will perform a test on a rowing ergometer Concept II USA each subject will have to cover a distance of 2000 m in the shortest possible time which is the distance starting in rowing competitions The results of both tests will be considered in the selection for the championship team therefore athletes will be well motivated to perform both tests with maximum effort
Hypotesis
The krill oil will infleunce the gut barier integrity
Research group the research will be conducted in a homogeneous group of professional rowers N30 all competitors qualified for the Polish Youth Rowing Team aged 18 - 24 The sample size was confiremed in statistical analyses
Rowing performance test will be conducted at the beginning and at the end of the training camp Participants will perform a test on a rowing ergometer Concept II USA each subject will have to cover a distance of 2000 m in the shortest possible time which is the distance starting in rowing competitions The results of both tests will be considered in the selection for the championship team therefore athletes will be well motivated to perform both tests with maximum effort
Hypotesis
The krill oil will infleunce the gut barier integrity
Detailed Description:
All competitors will be randomly divided into two groups double-blind
A supplemented n 15 who will receive one capsule of THYROX Atlantic krill oil four times a day
B control n 15 receiving placebo The supplementation period will be six weeks
Characteristic of the supplement
THYROX Atlantic krill oil The daily recommended intake of krill oil is 2000 mg which includes 350 mg of omega-3 fatty acids 240 mg of EPA 110 mg of DHA 800 mg of phospholipids and 200 mg of astaxanthin
Placebo will be produced by MLB Bitrade Sp z oo Poznan
Measurement The project contractors will measure all parameters using the available equipment in the ZWKF laboratory in Gorzów Wielkopolski and commercial assay kits
Polyethylene clotting activator tubes 9 ml will be centrifuged to separate the morphotic elements from the serum using a centrifuge 3000 rpm for 10 min The serum will be pipetted into several Eppendorf tubes then frozen temp -80 C All the following biochemical parameters will be determined from the extracted serum
using the ELISA method by the test manufacturers instructions The designations include the flowing parameters
a food diary will be filled day before the study and in the morning before the test markers of gut injury I-FABP intestinal fatty acid binding protein CLDN-3 claudin 3 intoxication LBP lipopolysaccharide binding protein stress hormones ACTH and cortisol will be determined using the colourimetric method on the SPECTROstar Nano reader
The lactate La concentration will be determined from the capillary blood immediately after collection using a commercially available kit Diaglobal Germany
A supplemented n 15 who will receive one capsule of THYROX Atlantic krill oil four times a day
B control n 15 receiving placebo The supplementation period will be six weeks
Characteristic of the supplement
THYROX Atlantic krill oil The daily recommended intake of krill oil is 2000 mg which includes 350 mg of omega-3 fatty acids 240 mg of EPA 110 mg of DHA 800 mg of phospholipids and 200 mg of astaxanthin
Placebo will be produced by MLB Bitrade Sp z oo Poznan
Measurement The project contractors will measure all parameters using the available equipment in the ZWKF laboratory in Gorzów Wielkopolski and commercial assay kits
Polyethylene clotting activator tubes 9 ml will be centrifuged to separate the morphotic elements from the serum using a centrifuge 3000 rpm for 10 min The serum will be pipetted into several Eppendorf tubes then frozen temp -80 C All the following biochemical parameters will be determined from the extracted serum
using the ELISA method by the test manufacturers instructions The designations include the flowing parameters
a food diary will be filled day before the study and in the morning before the test markers of gut injury I-FABP intestinal fatty acid binding protein CLDN-3 claudin 3 intoxication LBP lipopolysaccharide binding protein stress hormones ACTH and cortisol will be determined using the colourimetric method on the SPECTROstar Nano reader
The lactate La concentration will be determined from the capillary blood immediately after collection using a commercially available kit Diaglobal Germany
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None