Ignite Creation Date:
2024-05-06 @ 8:09 PM
Last Modification Date:
2024-10-26 @ 3:21 PM
Study NCT ID:
NCT06271343
Status:
RECRUITING
Last Update Posted:
2024-07-03
First Post:
2024-02-14
Brief Title:
Kidney Graft Tolerance KTOL
Sponsor:
Nantes University Hospital
Organization:
Nantes University Hospital
Study Overview
Official Title:
Non-interventional Single-center Study of the Contribution of DP8α Regulatory T Cells Induced by a Gut Microbiota Bacterium to Kidney Transplant Tolerance
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
KTOL
Brief Summary:
Prospective experimental study using PBMC from a limited number of adult patients 15 treated at Nantes University Hospital for a kidney transplant from a related living donor
The study will be carried out on PBMC from both donors and recipients collected during visits scheduled as part of the clinical management of the donorrecipient pair
The study will test the hypothesis that DP8α Tregs expressing CD73 whose frequency in blood increases stably after non-rejected kidney transplants but not when patients have undergone or will subsequently undergo rejection are enriched in donor-specific cells which would be a strong argument in favor of a direct role for these Tregs in preventing transplant rejection through their ability to inhibit immune responses directed against donor alloantigens
The study will be carried out on PBMC from both donors and recipients collected during visits scheduled as part of the clinical management of the donorrecipient pair
The study will test the hypothesis that DP8α Tregs expressing CD73 whose frequency in blood increases stably after non-rejected kidney transplants but not when patients have undergone or will subsequently undergo rejection are enriched in donor-specific cells which would be a strong argument in favor of a direct role for these Tregs in preventing transplant rejection through their ability to inhibit immune responses directed against donor alloantigens
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None