Ignite Creation Date:
2024-05-06 @ 8:08 PM
Last Modification Date:
2024-10-26 @ 3:21 PM
Study NCT ID:
NCT06262360
Status:
RECRUITING
Last Update Posted:
2024-02-21
First Post:
2024-02-06
Brief Title:
Changes in Pulmonary Ventilation Distribution Assessed by Electrical Impedance Tomography in Healthy Children Under General Anesthesia
Sponsor:
Queen Fabiola Childrens University Hospital
Organization:
Queen Fabiola Childrens University Hospital
Study Overview
Official Title:
Changes in Pulmonary Ventilation Distribution Assessed by EIT Electrical Impedance Tomography in Healthy Children Under General Anesthesia a Pilot Study Comparing Mask Spontaneous Breathing and Laryngeal Mask Spontaneous Breathing With and Without Ventilatory Support
Status:
RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
EIT_ped
Brief Summary:
The incidence of atelectasis is high in patients undergoing general anesthesia This may cause oxygenation impairment and further contribute to post-operative pulmonary complications As important airway management devices for general anesthesia few studies have compared the impact of laryngeal mask airway and spontaneous breathing on atelectasis Through the study the distribution of the pulmonary ventilation of children undergoing an elective and standard procedure in our center HUDERF will be studied using electric impedance tomography
Children from 1 year-old to 6-year-old ASA physical status I or II who will undergo elective circumcisions under general anesthesia associated with regional anesthesia Penile Block10 at the One Day Clinic of HUDERF Hôpital des Enfants Reine Fabiola - Brussels - Belgium
Patients will be allocated to three different group in a ration of 111
Group 1 spontaneous mask ventilation 20 patients
Group 2 spontaneous laryngeal mask LMA ventilation 20 patients
Group 3 spontaneous-pressure support LMA ventilation LMA SV-PS 20 patients
Standard monitoring for the inductions of the anesthesia will include non-invasive blood pressure NIBP pulse oximetry SpO2 Electrocardiogram ECG End-Tidal CO2 EtCO2 End Tidal Sevoflurane concentration EtSev inspired fraction of oxygen FiO2 body temperature rectal thermometer
Induction is based as well on the local routine protocols using an inhalation induction of the patient with Sevoflurane Fet of 6-8 and a recommended FiO2 from 80-90 maximum until the stabilization of the induction Then the FiO2 will be decreased at least under 40 and Sevoflurane adapted to the need of the deepness of the anesthesia both at the discretion of the anesthesiologist in charge of the patient
Depending on the randomization the patient will undergo the surgery either with spontaneous face mask ventilation group 1 LMA spontaneous ventilation group 2 or LMA SV-PS group 3 during which the pressure support will be adapted at the discretion of the anesthesiologist but with a tidal volume included in the range of 6-10mlkg
Electrical impedance tomography measurements
The effects of the spontaneous breathing mask ventilation or LMA or the pressure support ventilation LMA SV-PS on atelectasis formations and the distribution of the ventilation will be assessed using electrical impedance tomography
The device used during the study will be the PulmoVista 500 it will be provided by Dräger Lübeck Germany free of charge and without any obligation or resultsconclusions requested by Dräger The device is approved CE European regulation and will be used in the conditions for which it has been designed
A reusable belt with 16 evenly spaced electrodes will be placed around the chest of each patient included in the study between the 4th and 6th ribs as recommended by Dräger
The EIT measurements will be taken of 4 different moments
T1 Before induction of the anesthesia in the preoperatory waiting room and at least 30 min after the premedication
T2 After the induction of anesthesia GA and penile block just before the beginning of the surgical procedure
T3 After the end of the surgical procedure just before discontinuing the general anesthesia
T4 Before the discharge of the PACU
Children from 1 year-old to 6-year-old ASA physical status I or II who will undergo elective circumcisions under general anesthesia associated with regional anesthesia Penile Block10 at the One Day Clinic of HUDERF Hôpital des Enfants Reine Fabiola - Brussels - Belgium
Patients will be allocated to three different group in a ration of 111
Group 1 spontaneous mask ventilation 20 patients
Group 2 spontaneous laryngeal mask LMA ventilation 20 patients
Group 3 spontaneous-pressure support LMA ventilation LMA SV-PS 20 patients
Standard monitoring for the inductions of the anesthesia will include non-invasive blood pressure NIBP pulse oximetry SpO2 Electrocardiogram ECG End-Tidal CO2 EtCO2 End Tidal Sevoflurane concentration EtSev inspired fraction of oxygen FiO2 body temperature rectal thermometer
Induction is based as well on the local routine protocols using an inhalation induction of the patient with Sevoflurane Fet of 6-8 and a recommended FiO2 from 80-90 maximum until the stabilization of the induction Then the FiO2 will be decreased at least under 40 and Sevoflurane adapted to the need of the deepness of the anesthesia both at the discretion of the anesthesiologist in charge of the patient
Depending on the randomization the patient will undergo the surgery either with spontaneous face mask ventilation group 1 LMA spontaneous ventilation group 2 or LMA SV-PS group 3 during which the pressure support will be adapted at the discretion of the anesthesiologist but with a tidal volume included in the range of 6-10mlkg
Electrical impedance tomography measurements
The effects of the spontaneous breathing mask ventilation or LMA or the pressure support ventilation LMA SV-PS on atelectasis formations and the distribution of the ventilation will be assessed using electrical impedance tomography
The device used during the study will be the PulmoVista 500 it will be provided by Dräger Lübeck Germany free of charge and without any obligation or resultsconclusions requested by Dräger The device is approved CE European regulation and will be used in the conditions for which it has been designed
A reusable belt with 16 evenly spaced electrodes will be placed around the chest of each patient included in the study between the 4th and 6th ribs as recommended by Dräger
The EIT measurements will be taken of 4 different moments
T1 Before induction of the anesthesia in the preoperatory waiting room and at least 30 min after the premedication
T2 After the induction of anesthesia GA and penile block just before the beginning of the surgical procedure
T3 After the end of the surgical procedure just before discontinuing the general anesthesia
T4 Before the discharge of the PACU
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None