Ignite Creation Date:
2024-05-06 @ 8:08 PM
Last Modification Date:
2024-10-26 @ 3:21 PM
Study NCT ID:
NCT06262009
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-02-15
First Post:
2024-02-08
Brief Title:
Dynamics of AMR Spread Persistence and Evolution Between Humans Animals and Their Environment
Sponsor:
Assistance Publique - Hôpitaux de Paris
Organization:
Assistance Publique - Hôpitaux de Paris
Study Overview
Official Title:
Dynamics of AMR Spread Persistence and Evolution Between Humans Animals and Their Environment
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Dyaspeo
Brief Summary:
Humans in contact with animals such as dog owners may be at risk of antimicrobial resistance AMR acquisition This is the central issue to be investigated in DYASPEO
Detailed Description:
Antimicrobial resistance AMR is a global and multifaceted public health problem Advanced knowledge on AMR has demonstrated that it not only affects humans but is also widely distributed across animals and the environment A major cause of the AMR burden refers to the capability of AMR to transmit within and between individuals including between humans and animals Leading examples of internationally distributed AMR bacteria are Enterobacterial disseminating resistances to extended-spectrum cephalosporins ESC-E and carbapenems CP-E Yet the magnitude and pathways of their cross-sectorial transfers are poorly understood
There is a great concern that humans in contact with animals be at risk of ESC-ECP-E acquisition Whereas an increase in ESC-E carriage in farmers in contact with their food-producing animals was reported AMR transmission to humans through direct contacts with companion animals has been much less studied Owing the close relationships between pets and owners and the fact that 50 of households host a dog or a cat in France the hypothesis of pet ownership being a risk for humans to acquire ESC-ECP-E appears strongly relevant The DYASPEO project will investigate this question through a combination of several approaches from field to laboratory studies and including epidemiology ecology molecular and population genomics studies on intestinal microbiota modelling and social sciences
We hypothesize that the interface between humans and companion animals plays a significant role in the transfer of ESC-ECP-E This hypothesis is corroborated i by recent data in France showing that antibiotic exposure of companion animals is still increasing contrary to all other animal host eg food-producing animals and ii by a recent study from the consortium demonstrating a high AMR prevalence in dogs getting back home after hospitalization
There is a great concern that humans in contact with animals be at risk of ESC-ECP-E acquisition Whereas an increase in ESC-E carriage in farmers in contact with their food-producing animals was reported AMR transmission to humans through direct contacts with companion animals has been much less studied Owing the close relationships between pets and owners and the fact that 50 of households host a dog or a cat in France the hypothesis of pet ownership being a risk for humans to acquire ESC-ECP-E appears strongly relevant The DYASPEO project will investigate this question through a combination of several approaches from field to laboratory studies and including epidemiology ecology molecular and population genomics studies on intestinal microbiota modelling and social sciences
We hypothesize that the interface between humans and companion animals plays a significant role in the transfer of ESC-ECP-E This hypothesis is corroborated i by recent data in France showing that antibiotic exposure of companion animals is still increasing contrary to all other animal host eg food-producing animals and ii by a recent study from the consortium demonstrating a high AMR prevalence in dogs getting back home after hospitalization
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 2023-A02282-43 | OTHER | IDRCB | None |