Ignite Creation Date:
2024-05-06 @ 8:07 PM
Last Modification Date:
2024-10-26 @ 3:21 PM
Study NCT ID:
NCT06261515
Status:
RECRUITING
Last Update Posted:
2024-05-31
First Post:
2024-01-29
Brief Title:
Multi-omics Analysis of Oral-gut Microbial Profiles
Sponsor:
University of Turin Italy
Organization:
University of Turin Italy
Study Overview
Official Title:
Multi-omics Multi-specimens Evaluation of Oral-gut-systemic Profiles in Patients With Stage III-IV Periodontitis Pre- and After-therapy
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Periodontitis is a chronic inflammatory disease of the tooth supporting structures induced by a dysbiosis in the oral and subgingival microenvironment of susceptible patients The long-term swallowing of high doses of periodontal pathogenic microorganisms could induce a dysbiosis of the intestinal microbiota favouring the establishment of an inflamed microbiome in terms of composition andor function The present project is aimed at a better understanding of the etiopathogenetic correlation between periodontitis and intestinal dysbiosis and aims to explore the hypothesis that periodontal treatment may influence the multi-omics profile on the oral-gut-systemic axis 70 patients affected by stage III-IV periodontitis will be recruited and treated by means of full-mouth scaling and root planing Salivary subgingival plaque plasma and stool samples together with a complete periodontal charting and a food diary will be collected and compared at baseline and after treatment Age gender and BMI-matched healthy individuals will be recruited as controls
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None