Ignite Creation Date:
2024-05-06 @ 8:07 PM
Last Modification Date:
2024-10-26 @ 3:21 PM
Study NCT ID:
NCT06262529
Status:
RECRUITING
Last Update Posted:
2024-05-17
First Post:
2024-02-08
Brief Title:
Neurocognitive Impairment After Ischemic Stroke
Sponsor:
Centre Hospitalier Universitaire de Nice
Organization:
Centre Hospitalier Universitaire de Nice
Study Overview
Official Title:
Trajectories of Neurocognitive Impairment After Ischemic Stroke in Young Subjects
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
COG-TRA-Y MRI
Brief Summary:
Affecting more than 150000 patients in France stroke is a major public health issue and a leading cause of disability worldwide In western countries 80-85 of strokes are of ischemic subtype This study will focus on young adults aged 18-45 with a diagnosis of ischemic stroke
Studies assessing post-stroke cognition in young patients reported an alarming prevalence of cognitive impairment affecting about 60 of stroke survivors between 4 and 12 months after the acute event However longitudinal data on neurocognitive trajectories ie the evolution of cognitive impairment over time in young patients with ischemic stroke are lacking Collecting such data requires an exhaustive neuropsychological assessment and several functional evaluations at different times for the same patient
Repeated neurocognitive study of young patients with ischemic stroke will enable a description of the prevalence of impaired global cognitive efficiency an analysis of the specific neurocognitive domains affected and the tracing of trajectories of recovery from cognitive impairment over time in terms of global cognitive efficiency and as a function of specific neurocognitive domains memory executive attentional social cognition instrumental functions fatigability etc
Up to date the clinic-radiological predictors and associated factors of neurocognitive impairment after ischemic stroke in young patients have not been studied Ischemic stroke causes acute brain lesions of the gray matter GM and white matter WM Numerous studies suggest that cognitive health may be more closely linked to the integrity of WM than to GM Magnetic resonance imaging MRI and in particular diffusion tensor imaging DTI sequences analyze WM bundles By using fiber tracking algorithms image analysis enable the WM fiber bundle reconstruction and allow quantifying the volume of lesions pre-existing and ischemic stroke-induced in the WM tract
The aim of this study is to study whether the extension of pre-existing and acute white matter lesions is associated with poorer cognitive recovery after ischemic stroke both in terms of global cognitive performance and impairment in specific neurocognitive domains
Studies assessing post-stroke cognition in young patients reported an alarming prevalence of cognitive impairment affecting about 60 of stroke survivors between 4 and 12 months after the acute event However longitudinal data on neurocognitive trajectories ie the evolution of cognitive impairment over time in young patients with ischemic stroke are lacking Collecting such data requires an exhaustive neuropsychological assessment and several functional evaluations at different times for the same patient
Repeated neurocognitive study of young patients with ischemic stroke will enable a description of the prevalence of impaired global cognitive efficiency an analysis of the specific neurocognitive domains affected and the tracing of trajectories of recovery from cognitive impairment over time in terms of global cognitive efficiency and as a function of specific neurocognitive domains memory executive attentional social cognition instrumental functions fatigability etc
Up to date the clinic-radiological predictors and associated factors of neurocognitive impairment after ischemic stroke in young patients have not been studied Ischemic stroke causes acute brain lesions of the gray matter GM and white matter WM Numerous studies suggest that cognitive health may be more closely linked to the integrity of WM than to GM Magnetic resonance imaging MRI and in particular diffusion tensor imaging DTI sequences analyze WM bundles By using fiber tracking algorithms image analysis enable the WM fiber bundle reconstruction and allow quantifying the volume of lesions pre-existing and ischemic stroke-induced in the WM tract
The aim of this study is to study whether the extension of pre-existing and acute white matter lesions is associated with poorer cognitive recovery after ischemic stroke both in terms of global cognitive performance and impairment in specific neurocognitive domains
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None