Ignite Creation Date:
2024-05-06 @ 8:07 PM
Last Modification Date:
2024-10-26 @ 3:21 PM
Study NCT ID:
NCT06261671
Status:
RECRUITING
Last Update Posted:
2024-02-15
First Post:
2024-02-08
Brief Title:
Effect of Antioxydant-enriched Media on Blastocyst Euploidy Rates
Sponsor:
ART Fertility Clinics LLC
Organization:
ART Fertility Clinics LLC
Study Overview
Official Title:
Antioxidants-enriched Single-step vs Global Total Single-step Embryo Culture Media Effect on Blastocyst Euploidy Rates
Status:
RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
GX
Brief Summary:
One of the most sensible factors in IVF culture conditions is the susceptibility of gametes and embryos to an induced increase in reactive oxidative species ROS caused by the artificial environment This study aims to evaluate the impact of using antioxidant-supplemented media during culture to evaluate embryo ploidy rates in a prospective randomized trial using sibling oocytes
Detailed Description:
Improvements in culture conditions is an ongoing process in IVF due to on one hand the still lack of knowledge on human embryonic development and on the other hand the frequent need for repeated IVF cycles to achieve an implantable embryo The main factor for optimizing conditions of an embryo to develop is its microenvironment mainly the culture media used One of the most sensible factors in IVF culture conditions is the susceptibility of gametes and embryos to an induced increase in reactive oxidative species ROS caused by the artificial environment as it has been extensively shown in animal models and to a certain extent in humans
A primordial step for improvement is to alleviate an increase in ROS during embryo development This can be manipulated by means of utilizing a culture media with supplements that can serve as scavengers leading to an equilibrium between oxidation and reduction of ROS during the culture period So far the produced culture media contain low concentrations of limited additives involved in anti-oxidative stress Recently a culture medium containing an implementation in higher doses of distinctive elements known to clearly serve as cellular scavengers has been formulated However very few human IVF studies have been performed up to date Our research intends to investigate the incorporation of antioxidant-rich culture media into IVF practices with the primary objective of analyzing its impact on embryo euploidy as well as the previous culture steps including fertilization and blastocyst developmental rates This study aims to evaluate the impact of using antioxidant-supplemented media during culture to evaluate embryo ploidy rates in a prospective randomized trial using sibling oocytes
A primordial step for improvement is to alleviate an increase in ROS during embryo development This can be manipulated by means of utilizing a culture media with supplements that can serve as scavengers leading to an equilibrium between oxidation and reduction of ROS during the culture period So far the produced culture media contain low concentrations of limited additives involved in anti-oxidative stress Recently a culture medium containing an implementation in higher doses of distinctive elements known to clearly serve as cellular scavengers has been formulated However very few human IVF studies have been performed up to date Our research intends to investigate the incorporation of antioxidant-rich culture media into IVF practices with the primary objective of analyzing its impact on embryo euploidy as well as the previous culture steps including fertilization and blastocyst developmental rates This study aims to evaluate the impact of using antioxidant-supplemented media during culture to evaluate embryo ploidy rates in a prospective randomized trial using sibling oocytes
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None