Ignite Creation Date:
2024-05-06 @ 8:07 PM
Last Modification Date:
2024-10-26 @ 3:21 PM
Study NCT ID:
NCT06259708
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-02-14
First Post:
2024-01-26
Brief Title:
Using Low Intensity Focused Ultrasound to Modulate Deep Brain Areas for Tremor Control in Parkinsons Disease Patients
Sponsor:
University of British Columbia
Organization:
University of British Columbia
Study Overview
Official Title:
Effectiveness of Targeting the Zona Incerta ZI for Tremor Control in Parkinsons Disease Patients
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Researchers have found that a treatment called Magnetic Resonance guided Focused Ultrasound MRgFUS can effectively reduce tremors in patients with essential tremor ET and Parkinsons disease PD They noticed that ET patients initially responded better to the treatment than PD patients but by the end of the treatment both groups showed similar improvement The study also suggested that targeting a specific area of the brain called the Zona Incerta ZI may be more beneficial for PD patients Based on these findings the investigators plan to use low-intensity focused ultrasound to directly modulate the ZI area and investigate the mechanisms of reduced tremors in PD patients The investigators will also compare the effectiveness of this approach with the current target the ventral intermediate nucleus Vim of the thalamus The investigators will use a simulation model to determine the best ultrasound parameters for this new approach and will also examine the impact of the treatment on the brains network activity using functional Magnetic Resonance Imaging Success of this project may lay the foundation for finding a more effective target for MRgFUS treatment of PD tremor
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None