Ignite Creation Date:
2024-05-05 @ 11:21 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001665
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Transcranial Magnetic Stimulation for the Treatment of Parkinsons Disease
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Can Subthreshold Transcranial Magnetic Stimulation rTMS to Motor Cortex andor to Supplementary Motor Area SMA Improve Performance of Complex Motor Sequences in Parkinsons Disease
Status:
COMPLETED
Status Verified Date:
1999-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The problems in motor activity associated with Parkinsons disease are still poorly understood Patients with Parkinsons disease often suffer from extremely slow movements bradykinesia which result in the inability to perform complex physical acts
Imaging studies of the brain have provided researchers with information about the specific areas in the brain associated with these motor difficulties One particular area involved is the surface of the brain called the cerebral cortex
Transcranial Magnetic Stimulation TMS is a non-invasive technique that can be used to stimulate brain activity and gather information about brain function It is very useful when studying the areas of the brain related to motor activity motor cortex corticospinal tract and corpus callosum Repetitive transcranial magnetic stimulation rTMS involves the placement of a cooled electromagnet with a figure-eight coil on the patients scalp and rapidly turning on and off the magnetic flux This permits non-invasive relatively localized stimulation of the surface of the brain cerebral cortex The effect of magnetic stimulation varies depending upon the location intensity and frequency of the magnetic pulses
Researchers plan to study the therapeutic effects of repetitive transcranial magnetic stimulation rTMS on complex motor behavior of patients with Parkinsons disease In order to measure its effectiveness patients will be asked to perform complex tasks such as playing the piano while receiving transcranial magnetic stimulation
Imaging studies of the brain have provided researchers with information about the specific areas in the brain associated with these motor difficulties One particular area involved is the surface of the brain called the cerebral cortex
Transcranial Magnetic Stimulation TMS is a non-invasive technique that can be used to stimulate brain activity and gather information about brain function It is very useful when studying the areas of the brain related to motor activity motor cortex corticospinal tract and corpus callosum Repetitive transcranial magnetic stimulation rTMS involves the placement of a cooled electromagnet with a figure-eight coil on the patients scalp and rapidly turning on and off the magnetic flux This permits non-invasive relatively localized stimulation of the surface of the brain cerebral cortex The effect of magnetic stimulation varies depending upon the location intensity and frequency of the magnetic pulses
Researchers plan to study the therapeutic effects of repetitive transcranial magnetic stimulation rTMS on complex motor behavior of patients with Parkinsons disease In order to measure its effectiveness patients will be asked to perform complex tasks such as playing the piano while receiving transcranial magnetic stimulation
Detailed Description:
The physiology of the motor disturbance in Parkinsons disease is not completely understood One of the major and perhaps most disabling manifestations of PD is bradykinesia It is particularly difficult for these patients to perform simultaneous sequential and complex motor acts Imaging studies have recently provided important information in reference to the brain regions associated with performance of these motor sequences in normal volunteers and in PD patients These studies helped us to identify the brain regions active in association with task performance It has been suggested that cortical regions and particularly the SMA are less active in patients with PD than in controls in association with motor performance
We plan to study the effects of subthreshold rTMS delivered to SMA and primary motor cortex in patients with PD on and off medication From this study we expect to learn if stimulation of the scalp overlying primary motor cortex and SMA can ameliorate performance of simple and complex motor sequences in PD
Subthreshold rTMS has been proposed as a therapeutic tool in psychiatric disorders In the motor domain subthreshold rTMS delivered to primary motor cortex improves reaction times and motor performance in patients with Parkinsons disease The mechanisms underlying this beneficial effect are not known However they may be related with subthreshold rTMS replacing the missing excitatory drive on the motor cortex
We plan to study the effects of subthreshold rTMS delivered to SMA and primary motor cortex in patients with PD on and off medication From this study we expect to learn if stimulation of the scalp overlying primary motor cortex and SMA can ameliorate performance of simple and complex motor sequences in PD
Subthreshold rTMS has been proposed as a therapeutic tool in psychiatric disorders In the motor domain subthreshold rTMS delivered to primary motor cortex improves reaction times and motor performance in patients with Parkinsons disease The mechanisms underlying this beneficial effect are not known However they may be related with subthreshold rTMS replacing the missing excitatory drive on the motor cortex
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 97-N-0073 | None | None | None |